{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T16:10:09Z","timestamp":1749744609711,"version":"3.41.0"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"06","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objective: To determine the presentation, indications, management and clinical outcomes of patients who underwent trans-sphenoidal excision of pituitary adenomas in a tertiary care setting.\nMethod: The retrospective, descriptive study was conducted at the Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan, and comprised records of patients with pituitary adenoma who underwent trans-sphenoidal excision between July 2005 and September 2022. Data was analysed using STATA 15.1.\nResults: Of the 50 patients, 25(50%) were males and 25(50%) were females. The overall mean age was 43.16\u00b112 years. In 35(70%) cases, tumours were invading the cavernous sinus and were partially resected, 32(64%) tumours were macroadenoma, and 36(72%) were non-secretory. Of the total, 29(58%) patients were discharged within eight days of surgery. Intraoperative cerebrospinal fluid leak was seen in 4(8%) patients. Postoperative complications included anterior pituitary deficiency 17(34%), posterior pituitary deficiency 13(26%) and panhypopituitarism 3(6%). Postoperatively, vision improved in 23(46%) patients. External radiation therapy was offered to 15(30%) patients, while 5(10%) had gamma knife therapy.\nConclusion: Patients with non-functioning pituitary adenomas mostly presented later in life, with large adenomas causing compressive symptoms.\nKey Words: Pituitary adenoma, Endoscopic surgical procedure, Radiotherapy.<\/jats:p>","DOI":"10.47391\/jpma.20465","type":"journal-article","created":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T15:34:08Z","timestamp":1748792048000},"page":"926-930","source":"Crossref","is-referenced-by-count":0,"title":["Experience of trans-sphenoidal excision of pituitary adenomas in a tertiary care hospital in Pakistan"],"prefix":"10.47391","volume":"74","author":[{"family":"Maryam Butt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Noor Ul Huda Bhatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Mahnoor Tariq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Ibtissam Bin Khalid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Shayan Khalid Ghaloo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Irfan Yousaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2025,6,1]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/www.jpma.org.pk\/index.php\/public_html\/article\/download\/20465\/4149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jpma.org.pk\/index.php\/public_html\/article\/download\/20465\/4149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T15:42:30Z","timestamp":1749742950000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jpma.org.pk\/index.php\/public_html\/article\/view\/20465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,1]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2025,6,1]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.20465","relation":{},"ISSN":["0030-9982","0030-9982"],"issn-type":[{"type":"electronic","value":"0030-9982"},{"type":"print","value":"0030-9982"}],"subject":[],"published":{"date-parts":[[2025,6,1]]}}}