{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:16:25Z","timestamp":1781874985606,"version":"3.54.5"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"8","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objective: Observation of the clinical effect of Jiedu Shengji ointment in treating anal fistula and its impact on serum interleukin-6 and serum amyloid A.\nMethods: The clinical comparative study was conducted at Baoding No 1 Central Hospital, China, between January 2023 and February 2024, and comprised patients diagnosed with anal fistula who underwent surgery. The participants were randomly assigned to control group A which received dressing changes using Vaseline gauze, and intervention group B which was treated with Jiedu Shengji ointment in conjunction with Vaseline gauze. Treatment outcomes between the groups were compared. Data was analysed using SPSS 20.\nResults: Of the 60 patients, 30(50%) were in group A; 20(66.6%) men and 10(33.3%) women with mean age 32.56\u00b12.66 years (range: 22-43 years). There were 30(50%) patients in group B; 22(73.3%) men and 8(26.7%) women with mean age 32.14\u00b12.35 years (range: 22-42 years). Total effective rate of treatment in group B was 86.67% compared to 63.33% in group A (p&lt;0.05). After 7 and 14 days of treatment, the levels of interleukin-6 and serum amyloid A in group B were significantly better than those in group A (p&lt;0.05). The wound bleeding score, wound healing time, and wound oedema score of group B were significantly better than those of group A (p&lt;0.05). After treatment, the visual analogue scale and the Faecal Incontinence Severity Index scores of group B were significantly better than those of group A (p&lt;0.05). After treatment, the levels of transforming growth factor-Beta and epidermal growth factor in group B were significantly better than those in group A (p&lt;0.05).\nConclusion: Jiedu Shengji ointment demonstrated remarkable therapeutic efficacy in patients with surgical treatment for anal fistula.\nKey Words: Anal fistula, Jiedu Shengji ointment, Clinical efficacy, IL-6, SAA.<\/jats:p>","DOI":"10.47391\/jpma.20663","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:51:40Z","timestamp":1753890700000},"page":"1224-1228","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of effectiveness between two treatment methods for patients with anal fistula and their impact on serum IL-6 and SAA"],"prefix":"10.47391","volume":"75","author":[{"given":"Yi","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazhu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26547","published-online":{"date-parts":[[2025,1,28]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/20663\/4254","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/20663\/4254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T15:54:24Z","timestamp":1755014064000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/view\/20663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,28]]},"references-count":0,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,7,30]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.20663","relation":{},"ISSN":["0030-9982","0030-9982"],"issn-type":[{"value":"0030-9982","type":"electronic"},{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,28]]}}}