{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T20:18:20Z","timestamp":1783196300125,"version":"3.54.6"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"07","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objectives: To compare outcomes and severity parameters in patients with acute viral hepatitis and those with acute viral hepatitis and glucose-6-phosphate dehydrogenase deficiency.\nMethod: The retrospective, case-control study was conducted at Aga Khan University Hospital, Karachi, and comprised data from June 1, 2016, to January 31, 2022, related to patients with acute viral hepatitis having glucose-6-phosphate dehydrogenase deficiency in group A, and patients with acute viral hepatitis without G6PD deficiency in control group B. Data was analysed using SPSS 19.\nResults: Of the 27 male patients, 9 (33.3%) were in group A, with a mean age of 28.89 \u00b1 6.7 years, while group B had 18 (66.6%) patients, with a mean age of 28.11 \u00b1 8.6 years. There was no female subject in the sample. The haemoglobin levels were lower in group A patients (p=0.06). Total bilirubin, direct bilirubin, serum creatinine, and the length of hospital stay were significantly different between the groups (p&lt;0.05).\nConclusion: Acute hepatitis in patients with G6PD deficiency may present with a more severe course complicated by haemolysis, hyperbilirubinemia, acute liver failure, and acute kidney injury. Early recognition of G6PD deficiency is essential for appropriate monitoring and prevention of complications.\nKey Words: Hepatitis, Viral, Glucosephosphate dehydrogenase deficiency.<\/jats:p>","DOI":"10.47391\/jpma.21107","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T19:46:08Z","timestamp":1782503168000},"page":"1011-1014","source":"Crossref","is-referenced-by-count":0,"title":["The severity of acute viral hepatitis in patients with glucose-6-phosphate dehydrogenase deficiency: a case-control study"],"prefix":"10.47391","volume":"76","author":[{"given":"Mahrukh","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omair","family":"Ayaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zara","family":"Ghos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Om","family":"Parkash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26547","published-online":{"date-parts":[[2026,6,25]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/21107\/4893","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/21107\/4893","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T19:47:23Z","timestamp":1783194443000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/view\/21107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2026,6,23]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.21107","relation":{},"ISSN":["0030-9982"],"issn-type":[{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,25]]}}}