{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T02:47:17Z","timestamp":1746326837844},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objective: To see the efficacy of oral cholecalciferol administered to chronic kidney disease patients with vitamin D deficiency.\nMethods: The prospective interventional study was conducted at the Indus Hospital, Karachi, from January 11, 2017, to January 10, 2018, and comprised diagnosed pre-dialysis chronic kidney disease patients of either gender aged &gt;14 years having vitamin D deficiency. Oral vitamin D 50,000IU was given weekly to those who had severe deficiency &lt;10ng\/ml, and every other week to those with less severe 10-25ng\/ml deficiency for 3 months. Improvement in vitamin D level was checked along with other chronic kidney disease markers every month over the 3-month period. Data was analysed using SPSS 24.\nResults: Of the 186 patients enrolled, 129(%) completed the study; 76(58.5%) males and 53(40.8%) females. Overall, 105(81.4%) patients achieved normal vitamin D levels after 3 months of treatment. Significant negative but weak correlation of phosphate, creatinine and intact\u00a0parathyroid hormone levels was found with vitamin D (p&lt;0.05). Significant positive but weak correlation was found between albumin and vitamin D levels (p&lt;0.05).\nConclusion: Significant efficacy of oral vitamin D in chronic kidney disease patients was seen.<\/jats:p>","DOI":"10.47391\/jpma.2285","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T17:31:08Z","timestamp":1655919068000},"page":"1068-1074","source":"Crossref","is-referenced-by-count":2,"title":["Nutritional vitamin D is efficacious for reducing intact Parathyroid hormone in chronic kidney disease, a prospective interventional study"],"prefix":"10.47391","volume":"72","author":[{"given":"Shoukat","family":"Memon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Ashar Alam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Salman Imtiaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2022,6,22]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/ojs.jpma.org.pk\/index.php\/public_html\/article\/download\/2285\/1548","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T17:31:12Z","timestamp":1655919072000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.jpma.org.pk\/index.php\/public_html\/article\/view\/2285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,22]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6,22]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.2285","relation":{},"ISSN":["0030-9982"],"issn-type":[{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,22]]}}}