{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T15:10:02Z","timestamp":1735744202727,"version":"3.32.0"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"1","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objective: To analyse the aetiological spectrum, clinical presentation and short-term renal outcomes of patients withacute kidney injury of uncertain aetiology subjected to percutaneous renal biopsy.\nMethod: The prospective, cohort study was conducted at the Sindh Institute of Urology and Transplantation, Karachi,from March 1 to October 30, 2024, and comprised hospitalised acute kidney injury patients of either gender aged 18-75 years who had been subjected to percutaneous renal biopsy. The patients were followed up for at least threemonths from the time of the biopsy. Data was analysed using SPSS 26.\nResults: Of the 115 patients with mean age 32.61\u00b110.20 years, 60(52.2%) were females and 55(47.8%) were males.The mean estimated glomerular filtration rate was 23.05\u00b118.62ml\/min\/1.73m\u00b2. Over half 62 (53.9%) required kidneyreplacement therapy at presentation. Most patients 104(90.4%) had renal involvement due to glomerulopathy, whilethe rest exhibited non-glomerular renal disease. The most common primary glomerular diseases were focal segmentalglomerulosclerosis 26(22.6%), membranoproliferative glomerulonephritis 16(13.9%) and membranousnephropathy 4(3.5%). The leading secondary glomerular diseases were pauci-immune necrotising glomerulonephritis18(15.7%), thrombotic microangiopathy 16(13.9%) and lupus nephritis 8(7.0%). At 3-month follow-up, 43(37.4%)achieved complete recovery, 34(29.6%) achieved partial recovery and 38(33%) showed no recovery, while 4(3.4%)patients from the no recovery group expired at the time of the last follow-up. Patients who required kidneyreplacement therapy on admission had lower rates of complete recovery (p &lt;0.001), with more patients progressingto end-stage kidney disease (p=0.02) and increased mortality (p=0.08).\nConclusion: Most biopsied acute kidney injury patients had coexisting glomerular disease with worse renal recovery,while acute tubular necrosis alone was less frequent.\nKeywords: Acute kidney injury, End-stage kidney disease, Glomerular diseases, Kidney replacement therapy,Percutaneous renal biopsy.<\/jats:p>","DOI":"10.47391\/jpma.23005","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T14:29:19Z","timestamp":1735223359000},"page":"25-30","source":"Crossref","is-referenced-by-count":0,"title":["Etiological spectrum and short-term outcomes of acute kidney injury in hospitalised patients of uncertain aetiology who underwent percutaneous renal biopsy"],"prefix":"10.47391","volume":"75","author":[{"family":"Qazi Muhammad Huzaifa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Tabassum Elahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Sunbal Jahangir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Kalimullah Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Irum Memon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2024,12,23]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/23005\/3871","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/23005\/3871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T14:30:31Z","timestamp":1735741831000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/view\/23005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12,23]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.23005","relation":{},"ISSN":["0030-9982","0030-9982"],"issn-type":[{"type":"electronic","value":"0030-9982"},{"type":"print","value":"0030-9982"}],"subject":[],"published":{"date-parts":[[2024,12,23]]}}}