{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:39:13Z","timestamp":1773319153486,"version":"3.50.1"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"03","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objective: To investigate the relationship of clinico- pathological parameters with the histopathological spectrum of oral squamous cell carcinoma in a high-risk population.\nMethod: The prospective, cross-sectional study was conducted from January 2019 to September 2022 in the Khyber Pakhtunkhwa province of Pakistan, and comprised histologically confirmed cases of oral squamous cell carcinoma with a history of consumption of Naswar from different hospitals. The duration of use, age, site and histopathological features were recorded, and their association was explored. Data was analysed using SPSS 19.\nResults: Of the 80 patients with mean age 56.98\u00b112.94 years at diagnosis, 59(73%) were males and 21(26%) were females.\u00a0 Buccal mucosa was the predominant site of involvement 28(35%). Histologically, the most common presentation was well-differentiated squamous cell carcinoma 63(78.7%). The association of age and use duration with the histopathological pattern of oral squamous cell carcinoma was statistically non-significant (p&gt;0.05).\nConclusion: There was no significant association of age and prolonged Naswar use with histopathological patterns of oral squamous cell carcinoma.\nKeywords: Histopathology, Oral squamous cell carcinoma, Risk factors, Smokeless tobacco.<\/jats:p>","DOI":"10.47391\/jpma.23254","type":"journal-article","created":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T18:57:27Z","timestamp":1772391447000},"page":"387-391","source":"Crossref","is-referenced-by-count":0,"title":["Histopathological spectrum of oral squamous cell carcinoma in Naswar users: Correlation with duration, age and site"],"prefix":"10.47391","volume":"76","author":[{"given":"Fatima","family":"Iqbal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasiha","family":"Bashir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoor","family":"Maryam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajjad","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2026,3,1]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/23254\/4657","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/23254\/4657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:57:48Z","timestamp":1773255468000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/view\/23254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,1]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,3,1]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.23254","relation":{},"ISSN":["0030-9982","0030-9982"],"issn-type":[{"value":"0030-9982","type":"electronic"},{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,1]]}}}