{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T16:10:08Z","timestamp":1751559008983,"version":"3.41.0"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"07","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Fibroblast activation protein inhibitors (FAPI) PET is a new imaging approach that targets the cell population in the tumoursurrounding stroma, particularly cancer-associated fibroblasts, rather than tumour cells. 68Ga-FAPI PET\/CT FAPI PET\/CTprovides better lesion characterisation due to a higher tumour-to-background ratio and exhibits high diagnostic accuracy,especially for cancers that exhibit low-to-moderate uptake of 18F-FDG. We report the case of a 77-year-old woman withknown renal cell carcinoma treated ten years ago, and recently presented with cholangitis and a liver lesion. 18FDG PET-CTshowed a mild hypermetabolic lesion at segment V. 68Ga-FAPI PET\/CT was performed for further assessment. 68Ga-FAPIPET\/CT demonstrates an intensely tracer avid lesion at hepatic segment V. These findings are likely due to primarycholangiocarcinoma. Biopsy confirms intrahepatic cholangiocarcinoma. 68Ga-FAPI PET\/CT FAPI PET\/CT provides better lesioncharacterization due to a higher tumor-to-background ratio and exhibits high diagnostic accuracy in cholangiocarcinoma.\nKeywords: 68Ga-FAPI PET\/CT; Cholangiocarcinoma; Fibroblast activation protein; cancer-associated fibroblasts Biliary TractMalignancy.<\/jats:p>","DOI":"10.47391\/jpma.25-58","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T15:39:52Z","timestamp":1751470792000},"page":"1151-1152","source":"Crossref","is-referenced-by-count":0,"title":["68Ga-FAPI PET in detection of 18F-FDG PET Negative Cholangiocarcinoma: A Case Report on Alternative Molecular Imaging in Biliary Tract Malignancy"],"prefix":"10.47391","volume":"75","author":[{"family":"Sharjeel Usmani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Anjali Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Khulood al Riyami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Asiya al Busaidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Asim Jamal Shaikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2025,7,1]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/31896\/4242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/31896\/4242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T15:39:55Z","timestamp":1751557195000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/view\/31896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2025,7,1]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.25-58","relation":{},"ISSN":["0030-9982","0030-9982"],"issn-type":[{"type":"electronic","value":"0030-9982"},{"type":"print","value":"0030-9982"}],"subject":[],"published":{"date-parts":[[2025,7,1]]}}}