{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:09:43Z","timestamp":1777414183375,"version":"3.51.4"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"8","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>This review describes the relationship of splenomegaly, or\u201csplenic obesity\u201d, with metabolic syndrome, obesity andmetabolic \u2013 associated steatohepatic disease (MAFLD),based on animal and human studies. The spleen isenlarged in obesity. It may play a protective role againstobesity-associated inflammation and complications. Thisprotection may be lost after splenomegaly. Persons withsplenic disease must be evaluated for obesity, and viceversa and counselled to avoid injury to the organ.Keywords: MASLD, NAFLD, obesity, overweight, portalhypertension, spleen, splenectomy, weight<\/jats:p>","DOI":"10.47391\/jpma.25-63","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:46:09Z","timestamp":1753890369000},"page":"1298-1300","source":"Crossref","is-referenced-by-count":1,"title":["Obesity And The Spleen"],"prefix":"10.47391","volume":"75","author":[{"family":"Sanjay Kalra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Suneet Kumar Vermaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Nitin Kapoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2025,7,28]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/32285\/4271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/32285\/4271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T15:48:15Z","timestamp":1755013695000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/view\/32285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":0,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,7,30]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.25-63","relation":{},"ISSN":["0030-9982","0030-9982"],"issn-type":[{"value":"0030-9982","type":"electronic"},{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,28]]}}}