{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T21:18:01Z","timestamp":1770758281256,"version":"3.50.0"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"02","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Chronic Kidney Disease (CKD) is increasingly beingrecognized as an endo-metabolic disorder in which acascade of hormonal and electrolyte imbalances impactsthe morbidity and mortality. We propose six \u201cendocrinegiants\u201d of CKD- anaemia, secondary hyperparathyroidism,hypovitaminosis D, hypogonadism, hyperkalaemia, andhyponatraemia- each exerting a detrimental effect oncardiovascular, skeletal, metabolic, and neurological health.Their early recognition and prompt management canattenuate downstream cardiometabolic sequelae. This\u201cendocrine giants\u201d framework provides an integrativeapproach to managing CKD as a multisystem endocrinedisorder and offers practical direction for holisticnephrology care.Keywords: Chronic kidney disease, Anaemia, Secondaryhyperparathyroidism, Hypovitaminosis D, Hyperkalaemia,Hyponatraemia, Hypogonadism<\/jats:p>","DOI":"10.47391\/jpma.26-13","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T18:37:06Z","timestamp":1769711826000},"page":"269-271","source":"Crossref","is-referenced-by-count":0,"title":["The Endocrine Giants of Chronic Kidney Disease"],"prefix":"10.47391","volume":"76","author":[{"family":"Sourabh Sharma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Neha Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Sanjay Kalra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2026,1,27]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/40349\/4626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/40349\/4626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T18:40:11Z","timestamp":1770576011000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/view\/40349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2026,1,29]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.26-13","relation":{},"ISSN":["0030-9982","0030-9982"],"issn-type":[{"value":"0030-9982","type":"electronic"},{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,27]]}}}