{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T20:15:13Z","timestamp":1784060113735,"version":"3.55.0"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"8","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Stereotactic body radiotherapy (SBRT) may enhance synergistic effects of immunotherapies and radiotherapy (iRT), with the potential to induce abscopal effect in irradiated and non-irradiated sites. The case of a metastatic non-small-cell lung cancer (NSCLC) male patient with acquired immune checkpoint inhibitor (ICI) resistance (third-line setting) is reported.\u00a0 He received coeliac lymph node SBRT plus ICI re-challenge. This regimen induced abscopal effect on the patient\u2019s metastatic liver lesions. Despite negative PD-L1 expression and low tumour mutation burden (TMB) in liver biopsies, the patient achieved a progression-free survival (PFS) exceeding 12 months post-rechallenge, with 29 months of overall survival (OS) from initial ICI treatment (the follow-up ended in October 2021 due to the patient\u2019s death). Reports on draining lymph node (DLN) SBRT combined with ICI re-challenge in immunotherapy-resistant metastatic NSCLC remain scarce, especially when targeting coeliac lymph nodes. This case suggests that DLN SBRT plus ICIs could be a reasonable option for such immunotherapy-resistant patients.\nKeywords: Non-small-cell lung cancer; Immune checkpoint inhibitor; Stereotactic Body Radiotherapy; Abscopal effect; Draining lymph node; Rechallenge.<\/jats:p>","DOI":"10.47391\/jpma.31238","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T19:56:51Z","timestamp":1784059011000},"page":"1357-1360","source":"Crossref","is-referenced-by-count":0,"title":["Coeliac lymph nodes SBRT Combined with Immunotherapy Rechallenge Induce Abscopal Effect in Metastatic Non-Small-Cell Lung Cancer: A Case Report and Literature Review"],"prefix":"10.47391","volume":"76","author":[{"given":"Jing","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26547","published-online":{"date-parts":[[2026,7,12]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/31238\/4974","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/31238\/4974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T19:56:51Z","timestamp":1784059011000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/view\/31238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,12]]},"references-count":0,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,7,14]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.31238","relation":{},"ISSN":["0030-9982"],"issn-type":[{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,12]]}}}