{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T20:17:34Z","timestamp":1783196254389,"version":"3.54.6"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"07","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objectives: To analyse paediatric autoimmune hepatitis with respect to disease severity, treatment response, and clinical outcomes, including progression to liver failure and transplant survival.\nMethod: The retro-prospective study was conducted at the Pakistan Kidney and Liver Institute and Research Centre, Lahore, Pakistan, and comprised data from July 2019 to December 2024 of paediatric patients aged &lt;15 years diagnosed with autoimmune hepatitis. Demographic characteristics, clinical manifestations as well as laboratory and imaging findings were noted. Data was analysed using SPSS 27.\nResults: Of the 56 patients, 30(53.6%) were girls with mean age 9.94\u00b12.63 years, and 26(46.4%) were boys with mean age 9.24\u00b12.90 years. Autoimmune hepatitis type 1 was the predominant type 46(82.1%), while type 2 was found in 1(1.8%) patient and 9(16.1%) were seronegative. Jaundice was the most common symptom found in 54(96.4%) followed by ascites 28(50%) and abdominal pain 18(32.1%). \u00a0Histopathology of liver biopsies revealed features consistent with autoimmune hepatitis including statistically significant hepatocyte rosette formation (p-value= 0.100). Overall, 8 (14.3%) patients required liver transplantation.\nConclusion: The clinical spectrum of autoimmune hepatitis and its outcomes in children indicated there were significant diagnostic and therapeutic challenges that needed to be overcome.\nKey Words: Autoimmune diseases, Autoantibodies, Immunosuppressive agents, Liver biopsy, Liver transplantation.<\/jats:p>","DOI":"10.47391\/jpma.31965","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T19:42:04Z","timestamp":1782502924000},"page":"1117-1122","source":"Crossref","is-referenced-by-count":0,"title":["Clinical spectrum and outcomes of autoimmune hepatitis in children: a quaternary centre experience"],"prefix":"10.47391","volume":"76","author":[{"given":"Nazia","family":"Iqbal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqtadar","family":"Seerat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sobia","family":"Noureen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Bashir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26547","published-online":{"date-parts":[[2026,6,25]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/31965\/4917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/31965\/4917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T19:43:20Z","timestamp":1783194200000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/view\/31965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2026,6,23]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.31965","relation":{},"ISSN":["0030-9982"],"issn-type":[{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,25]]}}}