{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:00:23Z","timestamp":1780491623911,"version":"3.54.1"},"reference-count":0,"publisher":"Pakistan Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objective: To evaluate the outcomes, clinical and radiological application of Bone Morphogenetic Protein-2 alone versus Bone Morphogenetic Protein-2 with autograft in long bone non-unions.\nMethods: A prospective review of patients was done with fracture non-union admitted to Aga Khan University Hospital, Karachi, from January 2016 to January 2019. The patients were divided into two groups; those exposed to Bone Morphogenetic Protein-2 alone in group 1, and those exposed to Bone Morphogenetic Protein-2 plus autologous graft in group 2.\nResults: Background characteristics of both the groups were analysed. Patients were followed up at 6 and 12 weeks through their medical records. The primary outcome was postoperative union at 6 weeks or 12 weeks. Union was defined by having the clinical union as well as the radiological union at the same time of assessment. Of the 80 patients enrolled, 13(16.25%) were excluded, and 5(6.25%) were lost to follow-up. The final sample had 62(77.5%) patients; 35(56.5%) in group 1, and 27(43.5%) in group 2. Union at 6 weeks was observed in 13(21%) patients; 8(62%) in group 1, and 5(38%) in group 2. Union at 12 weeks was observed in 38(61%) patients; 20(53%) in group 1, and 18(47%) in group 2.\nConclusion: Results showed that using the adjuvant treatment alone was not worse than using it along with bone autologous graft.\nKey Words: Fracture, Non-union, Trauma, Bone-graft.\n\u00a0<\/jats:p>","DOI":"10.47391\/jpma.3312","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T08:17:13Z","timestamp":1644481033000},"source":"Crossref","is-referenced-by-count":2,"title":["An Audit of the effect of Bone Morphogenetic Protein-2 Treatment in patients with non-union of long bone fractures"],"prefix":"10.47391","author":[{"given":"Fateh Ali","family":"Janjua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Obada Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Fatima Abbas Naqvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Sarosh Madhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Masood Umer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26547","published-online":{"date-parts":[[2022,2,10]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T08:17:13Z","timestamp":1644481033000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.jpma.org.pk\/index.php\/public_html\/article\/view\/3312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,10]]},"references-count":0,"URL":"https:\/\/doi.org\/10.47391\/jpma.3312","relation":{},"ISSN":["0030-9982"],"issn-type":[{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,10]]}}}