{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:33:10Z","timestamp":1747225990869,"version":"3.40.5"},"reference-count":0,"publisher":"Pakistan Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Carcinoma ex pleomorphic adenoma is a neoplasm of the salivary gland that causes 3.6% of salivary gland tumours and 12% of salivary gland malignancies. It is a myoepithelial or epithelial neoplasm that arises from pleomorphic adenoma, whether primary or recurrent. Historically carcinoma ex pleomorphic adenoma is considered a high-grade malignancy. Salivary duct carcinoma and high-grade adenocarcinoma are the histologic types that most commonly arise in the background of Pleomorphic adenoma. However, 15% of tumours arising in Pleomorphic adenoma are considered low grade and have sluggish growth. Low-grade carcinoma ex pleomorphic adenoma can be difficult to differentiate from cellular pleomorphic adenoma.\nThe case of a 56-year-old female patient who had neck swelling is being presented. The biopsy showed spindle cell component with mild atypia, invasion into surrounding tissue, and increased mitotic activity on the basis\n---Continue<\/jats:p>","DOI":"10.47391\/jpma.3528","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T16:44:09Z","timestamp":1649695449000},"source":"Crossref","is-referenced-by-count":0,"title":["Myoepithelial Carcinoma arising in a background of pleomorphic adenoma"],"prefix":"10.47391","author":[{"given":"Nausheen","family":"Yaqoob","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7318-3053","authenticated-orcid":false,"given":"Salima","family":"Mansoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanwal","family":"Aftab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riyasat Ahmed","family":"Memon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saba","family":"Jamal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2022,4,11]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"deposited":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T16:44:09Z","timestamp":1649695449000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.jpma.org.pk\/index.php\/public_html\/article\/view\/3528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.47391\/jpma.3528","relation":{},"ISSN":["0030-9982"],"issn-type":[{"type":"print","value":"0030-9982"}],"subject":[],"published":{"date-parts":[[2022,4,11]]}}}