{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T21:18:41Z","timestamp":1650575921584},"reference-count":0,"publisher":"Pakistan Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objective: To assess the safety of dermatological 0.1% tacrolimus ointment when used topically and its efficacy in the treatment of vernal keratoconvinctivtis.\nMethod: The quasi-experimental, multi-centre study was conducted at the Gujranwala Medical College\/District Headquarters Teaching Hospital, Gujranwala, and the Gomal Medial College\/Mufti Mehmood Teaching Hospital, Dera Ismail Khan, Pakistan, from July 2019 to March 2020, and comprised patients of severe vernal keratoconvinctivtis. Symptoms and clinical signs were graded on a pre-devised scale. Patients were given small amount of tacrolimus 0.1% ointment applied to the inferior conjunctival fornix before going to bed. The duration of treatment was 3 months and the patients were followed up for up to 6 months. Data was analysed using SPSS 20.\nResults: Of the 50 patients, 30(60%) were males and 20(40%) were females. The overall mean age was 10.64\u00b13.199 years. Mean symptom score and clinical signs score gradually reduced on each follow-up (p&lt;0.05). Mild recurrence was noted in 12(24%) patients who were managed with lubricants and anti-histamine topical drops. No complication was noted.\nConclusion: Tacrolimus 0.1% was found to be effective and safe in the treatment of severe refractory vernal keratoconvinctivtis even when given once a day.\nClinical Trial Registration: Chinese Clinical Trial Registry Id: ChiCTR2000031929 link: www.chictr.org.cn\/hvshowproject.aspx?id=28053\nKey Words: Allergic, Conjunctivitis, Tacrolimus, Topical administration, Anti-allergic agents, Dermatologic agents, Efficacy.<\/jats:p>","DOI":"10.47391\/jpma.3541","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T16:49:16Z","timestamp":1650473356000},"source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of single dose dermatological 0.1% tacrolimus Ointment in the treatment of vernal keratoconjunctivitis"],"prefix":"10.47391","author":[{"given":"Muhammad","family":"Sharjeel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usama","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aamna","family":"Jabran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asif","family":"Mehmood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Memona","family":"Mohiuddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2022,4,19]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"deposited":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T16:49:17Z","timestamp":1650473357000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.jpma.org.pk\/index.php\/public_html\/article\/view\/3541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,19]]},"references-count":0,"URL":"https:\/\/doi.org\/10.47391\/jpma.3541","relation":{},"ISSN":["0030-9982"],"issn-type":[{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,19]]}}}