{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T04:57:03Z","timestamp":1667710623981},"reference-count":0,"publisher":"Pakistan Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>The Guillain-Barr\u00e9 syndrome is an autoimmune polyradiculoneuropathy causing symmetrical weakness of limbs. After poliomyelitis, it is the second most common cause of paralysis, with an annual incidence of 0.84-1.91 per 100,000 individuals. The syndrome affects both men and women, showing a male preponderance.\u00a0Campylobacter jejuni, epstein-barr virus, cytomegalovirus, mycoplasma pneumoniae and hemophilus influenzae are amongst the most common causative agents of Guillain-Barr\u00e9 syndrome. Several immunological and genetic factors have been recognised as the risk factors. Human leukocyte antigen, cluster of differentiation 1, and tumor necrosis factor-alpha alleles are among the frequently investigated loci in Guillain-Barr\u00e9 syndrome. Genome-wide association studies have found no significant association of Guillain-Barr\u00e9 syndrome with common variants. Many vaccines against Campylobacter jejuni infection have been proposed, but there are concerns about the efficacy and safety of these vaccines. So far, there is no approved vaccine against Campylobacter jejuni.<\/jats:p>","DOI":"10.47391\/jpma.5369","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T08:00:23Z","timestamp":1667635223000},"source":"Crossref","is-referenced-by-count":0,"title":["Antecedent infections, recent developments and future directions in Guillain-Barr\u00e9 syndrome"],"prefix":"10.47391","author":[{"given":"Rashid","family":"Iqbal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Javaid","family":"Asad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja Tahir","family":"Mahmood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Basir","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahida","family":"Nawaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saima","family":"Siddiqi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Admin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2022,11,5]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"deposited":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T08:00:23Z","timestamp":1667635223000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.jpma.org.pk\/index.php\/public_html\/article\/view\/5369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,5]]},"references-count":0,"URL":"https:\/\/doi.org\/10.47391\/jpma.5369","relation":{},"ISSN":["0030-9982"],"issn-type":[{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,5]]}}}