{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:47:39Z","timestamp":1790711259256,"version":"4.1.0"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objective: To evaluate children with suspected or definite hypervitaminosis D with respect to prevalence, clinical manifestations and pharmacological aspects.\nMethod: The retrospective cross-sectional study was conducted at the Aga Khan University Hospital, Karachi, and comprised medical records from January 1 to December 31, 2018, of children aged &lt;18 years with 25-hydroxyvitamin D levels &gt;50ng\/ml. Clinical and pharmacological data was retrieved. Data was analysed using SPSS 23.\nResults: Of the 118,149 subjects visiting the clinical laboratory during the study period, children tested for serum 25-hydroxyvitamin D levels were 16,316(13.8%) who had a median age of 9.78 years (interquartile range: 10.2 years). Children who registered for consultation were 2720(16.6%), and, out of them, 602(22%) had serum 25-hydroxyvitamin D &gt;50ng\/ml. The median 25-hydroxyvitamin D levels and age were 70.1ng\/ml (interquartile range: 100ng\/ml) and 3.1 years (interquartile range: 17.93 years), respectively, and 345(57.3%) of them were boys. Children supplemented with vitamin D were 197(33.1%) and 193(97.9%) of them were prescribed by physicians. Mega-doses were taken by 68(34.17%), while the remaining had used various combinations in syrup or tablet forms. Commonly prescribed mega-doses were 600,000IU 30((44.1%) and 200,000IU 31(45.5%) injections of vitamin D. The primary indications were pains\/aches in 51(25.8%) cases, developmental delay 50(25.3%), and vitamin D deficiency 49(24.8%). The main symptoms of hypervitaminosis D or toxicity were abdominal pain 27(13.7%) and constipation 31(15.7%).\nConclusions: Children should be given vitamin D supplements with caution as prolonged supplementation and repeated mega-doses can result in toxicity which may cause serious consequences.\nKey Words: Vitamin D deficiency, Vitamin D supplements, Hypervitaminosis D, Vitamin D toxicity.<\/jats:p>","DOI":"10.47391\/jpma.5512","type":"journal-article","created":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T04:55:19Z","timestamp":1677992119000},"page":"500-505","source":"Crossref","is-referenced-by-count":6,"title":["Inappropriate supplementation of Vitamin D can result in toxicity: a cross-sectional study of paediatrics population"],"prefix":"10.47391","volume":"73","author":[{"given":"Nazia","family":"Shamim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafsa","family":"Majid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneeta","family":"Khemani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maliha","family":"Salim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siraj","family":"Muneer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysha Habib","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"26547","published-online":{"date-parts":[[2023,3,4]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"deposited":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T04:55:30Z","timestamp":1678078530000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.jpma.org.pk\/index.php\/public_html\/article\/view\/5512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,4]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3,4]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.5512","relation":{},"ISSN":["0030-9982"],"issn-type":[{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3,4]]}}}