{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:33:18Z","timestamp":1747225998861,"version":"3.40.5"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"4","license":[{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objective: To assess associations between various clinic-demographic factors and clinical outcomes among patients treated for sepsis.\nMethods: The retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised data of all patients aged &gt;18 years diagnosed with sepsis from January to December 2019. Multivariable logistic regression was used to evaluate independent associations between predictors and outcomes. Data was analysed using R packages.\nResults: Of the 1,136 patients, 621(54.6%) were male and 515(45.3%) were female. The overall mean age was 59.05\u00b116.91 years. Female gender (odds ratio: 1.029; 95% confidence interval: 1.03-1.64) to be an independent predictor of septic shock, while hypertension (odds ratio0.75; 95% confidence interval: 0.59-0.95) emerged as a protective factor. Chronic kidney disease (odds ratio: 1.539; 95% confidence interval: 1.14-2.07) was an independent predictor of prolonged length of stay, while older age appeared to be protective (odds ratio: 0.98; 95% confidence interval: 0.98-0.99). Mortality was associated with a significantly lower odds of Escherichia coli on culture (odds ratio: 0.26; 95% confidence interval: 0.12-0.54).\nConclusion: Independent associations were found between specific patient characteristics and adverse clinical outcomes.\nKey Words: Sepsis, Septic shock, Mortality, Morbidity.<\/jats:p>","DOI":"10.47391\/jpma.6818","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T05:40:52Z","timestamp":1708407652000},"page":"608-612","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of clinical outcomes in patients with sepsis: a retrospective study from a tertiary care hospital in Pakistan"],"prefix":"10.47391","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4490-4453","authenticated-orcid":false,"given":"Meher","family":"Angez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Jassani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manzar","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inaara","family":"Akbar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Russell Seth Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Ainan Arshad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2024,2,11]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/ojs.jpma.org.pk\/index.php\/public_html\/article\/download\/6818\/3055","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ojs.jpma.org.pk\/index.php\/public_html\/article\/download\/6818\/3055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T05:41:22Z","timestamp":1708494082000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.jpma.org.pk\/index.php\/public_html\/article\/view\/6818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,11]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,2,15]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.6818","relation":{},"ISSN":["0030-9982"],"issn-type":[{"type":"print","value":"0030-9982"}],"subject":[],"published":{"date-parts":[[2024,2,11]]}}}