{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T00:51:04Z","timestamp":1701478264791},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"12","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Dear Editor,\nMy purpose in writing this letter is to draw your attention to a very susceptible situation of possible adverse reactions like hepatotoxicity caused by Nimesulide. It is being prescribed as an over-the-counter drug and is available even online for home delivery without any prescription in Pakistan.\nNimesulide is an atypical selective COX-2 inhibitor that is similar in anti-inflammatory effects as compared to other classical NSAIDs and selective COX-2 (celecoxib &amp; rofecoxib) inhibitors but different as it has a protective effect on NSAID-induced ulcers as compared to other more selective COX-2 inhibitors, which do prevent but do not protect NSAID induced ulcers.\nBut, does this only benefit of being gastroprotective justify its use as a relatively common drug with or without a prescription?\n---Continue<\/jats:p>","DOI":"10.47391\/jpma.9593","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T05:18:41Z","timestamp":1701407921000},"page":"2511-2511","source":"Crossref","is-referenced-by-count":0,"title":["Nimesulide: A double-edged sword must be banned"],"prefix":"10.47391","volume":"73","author":[{"given":"Muhammad Moaz","family":"Bin Khalid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Muhammad Nouman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2023,11,28]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/www.ojs.jpma.org.pk\/index.php\/public_html\/article\/download\/9593\/2870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ojs.jpma.org.pk\/index.php\/public_html\/article\/download\/9593\/2870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T05:18:41Z","timestamp":1701407921000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ojs.jpma.org.pk\/index.php\/public_html\/article\/view\/9593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,28]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12,1]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.9593","relation":{},"ISSN":["0030-9982"],"issn-type":[{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11,28]]}}}