{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:19:01Z","timestamp":1720916341459},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"6 (Supple)","license":[{"start":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T00:00:00Z","timestamp":1720310400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Ventricular Septal Rupture (VSR) is a rare complication ofacute myocardial infarction and has a high mortality rate.Surgery is the definitive treatment. However, in hospitalswith limited facilities, treating acute myocardial infarctionpatients with ventricular septal rupture, is challenging. A74-year-old woman came to the emergency room of Dr.Koesma General Hospital, Tuban, East Java in December,2019 with late-onset Acute Myocardial Infarction. On thefollowing day, a new holosystolic murmur was heard inthe left lower sternal border with palpable thrill.Transthoracic echocardiography showed VSR with severepulmonary hypertension. This was followed by a drop inthe blood pressure to 80\/50 mmHg. The blood pressurewas dependent on vasopressors until lisinopril andcoenzyme Q10 were introduced. After 3 months, thehaemodynamics of the patient were stable. This provedthat the use of angiotensin-converting enzyme andcoenzyme Q10 promotes more energy production,enables tissue healing and leads to balanced remodellingto increase the survival rate in cases of non-surgicaltreatment.Keywords: Lisinopril, Ventricular Septal Rupture, HeartMurmurs, Vasoconstrictor, Hemodynamics, Angiotensin\u2019s,Infarction, Coenzymes<\/jats:p>","DOI":"10.47391\/jpma.s6-acsa-16","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T13:57:34Z","timestamp":1720879054000},"page":"S81-S84","source":"Crossref","is-referenced-by-count":0,"title":["Angiotensin converting enzyme inhibitor and coenzyme Q10 as adjunctive treatment for patients with ventricular septal rupture following late onset myocardial infarction: a case report"],"prefix":"10.47391","volume":"74","author":[{"family":"Ryan Enast Intan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Dimas Rio Balti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Ricardo Adrlan Nugraha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Firas Farisi Alkaff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Sovia Salamah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Tan Nicko Octora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2024,7,7]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/21463\/3400","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/download\/21463\/3400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T13:57:34Z","timestamp":1720879054000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpma.org.pk\/index.php\/public_html\/article\/view\/21463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,7]]},"references-count":0,"journal-issue":{"issue":"6 (Supple)","published-online":{"date-parts":[[2024,7,13]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.s6-acsa-16","relation":{},"ISSN":["0030-9982","0030-9982"],"issn-type":[{"value":"0030-9982","type":"electronic"},{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7,7]]}}}