{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:11:22Z","timestamp":1759684282254,"version":"build-2065373602"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"7 (July) (Supple-02)","license":[{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objective:To investigate the predictive value of transvaginal three-dimensional ultrasound combined with serum oestrogenand progesterone levels in enhancing the clinical pregnancy rate of in vitro fertilization-embryo transfer.Method: The study was conducted at the Reproductive and Women-Children Hospital, Chengdu University of TraditionalChinese Medicine, Chengdu, China, from September 2020 to March 2021, and comprised patients undergoing in vitrofertilization-embryo transfer with frozen-thawed embryo cycles. The day before embryo implantation, endometrial thicknessand sub-endometrial blood flow parameters were measured using two-dimensional ultrasound and then converted tothree-dimensional ultrasound mode to assess endometrial volume and sub-endometrial vascularisation parameters. Serumestradiol and progesterone levels were also measured on the day of transplantation. The subjects were categorised intopregnancy and non-pregnancy groups based on their outcomes. The correlation of two-dimensional and three-dimensionalultrasound parameters was compared alongside serum estradiol and progesterone levels with respect to clinical pregnancyoutcomes. Data was analysed using SPSS 22.Results: Of the 100 women with mean age 32.8\u00b18.3 years (range: 22-44 years), 56(56%) were in the clinical pregnancygroup and 44(44%) were in the non-pregnancy group. There was no significant differences in endometrial thickness or twodimensionalultrasound sub-endometrial blood flow parameters between the groups (p&gt;0.05). In contrast, endometrialvolume and three-dimensional sub-endometrial vascularisation indices were significantly higher in the pregnancy group(p&lt;0.05). Combining endometrial volume with serum estradiol levels yielded a predictive accuracy with area under thecurve 0.735, sensitivity 77.3% and specificity 90.7%.Conclusion:Transvaginal three-dimensional ultrasound-derived endometrial volume and sub-endometrial vascularisationparameters, combined with serum estradiol levels, could significantly improve the prediction of clinical pregnancy successin cases of in vitro fertilization-embryo transfer.Keywords: Transvaginal three-dimensional ultrasound, Oestrogen level, Endometrial receptivity, In vitro fertilizationembryotransfer.<\/jats:p>","DOI":"10.47391\/jpma.srph-08","type":"journal-article","created":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:52:37Z","timestamp":1759683157000},"source":"Crossref","is-referenced-by-count":0,"title":["Predicting Clinical Pregnancy Rates in IVF-ET Using Transvaginal 3D Ultrasound and Serum Hormone Levels"],"prefix":"10.47391","volume":"75","author":[{"family":"Ling Lan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"DanYang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"XinTan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Yu Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2025,10,4]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/www.jpma.org.pk\/index.php\/public_html\/article\/download\/33011\/4402","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jpma.org.pk\/index.php\/public_html\/article\/download\/33011\/4402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:52:37Z","timestamp":1759683157000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jpma.org.pk\/index.php\/public_html\/article\/view\/33011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,4]]},"references-count":0,"journal-issue":{"issue":"7 (July) (Supple-02)","published-online":{"date-parts":[[2025,10,5]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.srph-08","relation":{},"ISSN":["0030-9982","0030-9982"],"issn-type":[{"value":"0030-9982","type":"electronic"},{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,4]]}}}