{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:12:17Z","timestamp":1759684337367,"version":"build-2065373602"},"reference-count":0,"publisher":"Pakistan Medical Association","issue":"7 (July) (Supple-02)","license":[{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pak Med Assoc"],"abstract":"<jats:p>Objective:To explore the effect of novel nosocomial infection prevention and control combined with intestinal probioticsin children with hand, foot and mouth disease.Methods: The randomised case-control study was conducted at the Hunan Children\u2019s Hospital, Changsha, China, fromJanuary 2022 to December 2023, and comprised of paediatric inpatients with hand, foot and mouth disease. The patientswere randomised into control Group 1 receiving conventional treatment with basic nursing services, and intervention Group2 receiving bacillus coagulans live tablets along with novel nosocomial infection prevention and control measures. Thetime of symptom resolution, fever resolution, length of hospital stay, clinical effect, serum inflammatory factors, immunefunction, incidence of adverse reactions, quality of life and parents\u2019 satisfaction with nursing were noted and comparedbetween the groups. Data was analysed using SPSS 22.0.Results: Of the 100 patients, 50(50%) were in Group 1; 25(50%) boys and 25(50%) girls with mean age 3.49\u00b11.93 years.There were 50(50%) patients in Group 2; 26(52%) boys and 24(48%) girls with mean age 3.52\u00b12.03 years (p&gt;0.05). Comparedto Group 1, patients in Group 2 had shorter time of symptom resolution, fever resolution, length of hospital stay, bettertotal effective rate, lower frequency of adverse reactions and higher nursing satisfaction (p&lt;0.05). After the intervention,improvements in serum inflammatory factors in Group 2 were more significant, the immune function indexes were higher,and the quality of life scores were better compared to Group 1 (p&lt;0.05).Conclusion: Novel nosocomial infection prevention and control combined with intestinal probiotics could promote thetherapeutic effect of the children, improve the immune function, and promote the quality of life of children with hand, footand mouth disease.Keywords: Hand, foot and mouth disease, Nosocomial infection, Prevention and control, Intestinal probiotics, Immunefunction.<\/jats:p>","DOI":"10.47391\/jpma.srph-22","type":"journal-article","created":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:50:10Z","timestamp":1759683010000},"source":"Crossref","is-referenced-by-count":0,"title":["Application of novel nosocomial infection prevention and control combined with intestinal probiotics in children with hand, foot and mouth disease"],"prefix":"10.47391","volume":"75","author":[{"family":"Yuqiong Tao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Huibin Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Jinlian Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"E Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Xiaoyan Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Jianhui Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26547","published-online":{"date-parts":[[2025,10,4]]},"container-title":["Journal of the Pakistan Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/www.jpma.org.pk\/index.php\/public_html\/article\/download\/33063\/4420","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jpma.org.pk\/index.php\/public_html\/article\/download\/33063\/4420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:50:10Z","timestamp":1759683010000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jpma.org.pk\/index.php\/public_html\/article\/view\/33063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,4]]},"references-count":0,"journal-issue":{"issue":"7 (July) (Supple-02)","published-online":{"date-parts":[[2025,10,5]]}},"URL":"https:\/\/doi.org\/10.47391\/jpma.srph-22","relation":{},"ISSN":["0030-9982","0030-9982"],"issn-type":[{"value":"0030-9982","type":"electronic"},{"value":"0030-9982","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,4]]}}}