{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:34:21Z","timestamp":1747226061573,"version":"3.40.5"},"reference-count":0,"publisher":"Instituto Nacional Cardovascular - Carlos Alberto Peschiera Carrillo","issue":"4","license":[{"start":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Peru Cardiol Cir Cardiovasc"],"abstract":"<jats:p>Homozygous familial hypercholesterolemia (HFH) is a rare and life-threatening disease that can manifest as coronary artery disease or severe aortic stenosis before twenties. We present the case of a male adolescent who was hospitalized with a clinical diagnosis of HFH and severe aortic stenosis. He underwent aortic valve replacement with mechanical prosthesis and aortic annulus enlargement, and two aortocoronary bypasses were implanted due to an intraoperative complication. The patient evolved favourably and was discharged with combination therapy with high-intensity statins and ezetimibe.<\/jats:p>","DOI":"10.47487\/apcyccv.v2i4.166","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T16:20:46Z","timestamp":1642004446000},"page":"268-273","source":"Crossref","is-referenced-by-count":0,"title":["Estenosis a\u00f3rtica severa e hipercolesterolemia familiar","Severe aortic stenosis and familial hypercholesterolemia"],"prefix":"10.47487","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4520-1717","authenticated-orcid":false,"given":"Milagros","family":"Mallma G\u00f3mez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9678-3729","authenticated-orcid":false,"given":"Josafat","family":"Condori Ccallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4799-2134","authenticated-orcid":false,"given":"David","family":"Miranda No\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26947","published-online":{"date-parts":[[2021,12,27]]},"container-title":["Archivos Peruanos de Cardiolog\u00eda y Cirug\u00eda Cardiovascular"],"original-title":[],"link":[{"URL":"https:\/\/apcyccv.org.pe\/index.php\/apccc\/article\/download\/166\/265","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/apcyccv.org.pe\/index.php\/apccc\/article\/download\/166\/265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T06:02:12Z","timestamp":1719122532000},"score":1,"resource":{"primary":{"URL":"https:\/\/apcyccv.org.pe\/index.php\/apccc\/article\/view\/166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,27]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,12,30]]}},"URL":"https:\/\/doi.org\/10.47487\/apcyccv.v2i4.166","relation":{},"ISSN":["2708-7212"],"issn-type":[{"type":"electronic","value":"2708-7212"}],"subject":[],"published":{"date-parts":[[2021,12,27]]}}}