{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:19:19Z","timestamp":1765808359703,"version":"3.40.5"},"reference-count":0,"publisher":"Instituto Nacional Cardovascular - Carlos Alberto Peschiera Carrillo","issue":"2","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Peru Cardiol Cir Cardiovasc"],"abstract":"<jats:p>Objectives. Patients diagnosed with transthyretin amyloid cardiomyopathy (ATTR-CM) often experience\u00a0poor outcomes due to the development of heart failure (HF). Tricuspid regurgitation (TR) has been found\u00a0to be correlated with adverse outcomes in patients with HF. This study aims to assess whether the presence\u00a0of significant TR is associated to adverse cardiac outcomes in patients diagnosed with ATTR-CM. Materials\u00a0and methods. Retrospective study of ATTR-CM patients enrolled in the Institutional Registry of Amyloidosis\u00a0(NCT01347047). Patients were categorized based on the presence of significant TR (moderate or severe\u00a0according to current guidelines criteria) or absence of significant TR. All patients were followed up for 2\u00a0years to assess the incidence of the composite outcome of death or HF hospitalization. Results. A total of\u00a093 ATTR-CM patients were included. The mean age at diagnosis was 82.5 [IQR 75 - 86] years, 86% were male,\u00a0and the mean left ventricular ejection fraction was 52% [IQR 43 - 60]. Among them, 32.3% (n = 30) patients\u00a0had significant TR. Patients with significant TR had higher NTpro-BNP values (5308 vs 2454, pg\/mL, p =\u00a00.004), and a lower left ventricular ejection fraction (44 vs. 56%, p = 0.0002) compared to patients without\u00a0significant TR. The incidence of the primary outcome was higher in patients with significant TR (77% vs. 30%,\u00a0p&lt;0.001). In a multivariate Cox regression analysis, only NTpro-BNP, as a numerical variable (HR 1.00, 95%\u00a0CI 1.00005-1.0002, p = 0.001), and significant TR (HR 2.23, 95% CI 1.12-4.42, p=0.021) were independently\u00a0associated with the composite outcome of death or HF hospitalization. Conclusions. In patients diagnosed\u00a0with ATTR-CM, the presence of significant TR was associated with worse outcomes.<\/jats:p>","DOI":"10.47487\/apcyccv.v5i2.388","type":"journal-article","created":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T01:12:02Z","timestamp":1719105122000},"page":"80-86","source":"Crossref","is-referenced-by-count":1,"title":["Significant tricuspid regurgitation is associated with adverse outcomes in patients with transthyretin amyloid cardiomyopathy"],"prefix":"10.47487","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1186-4376","authenticated-orcid":false,"given":"Santiago","family":"Decotto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7264-6874","authenticated-orcid":false,"given":"Juan Mar\u00eda","family":"Iroulart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5786-5470","authenticated-orcid":false,"given":"Guido","family":"Roveda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7100-4349","authenticated-orcid":false,"given":"Eugenia","family":"Villanueva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1403-7069","authenticated-orcid":false,"given":"Mar\u00eda Adela","family":"Aguirre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1403-7069","authenticated-orcid":false,"given":"Mar\u00eda Lourdes","family":"Posadas-Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2177-7727","authenticated-orcid":false,"given":"Elsa","family":"Nucifora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8063-8820","authenticated-orcid":false,"given":"Rodolfo","family":"Pizarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8582-5065","authenticated-orcid":false,"given":"Diego","family":"P\u00e9rez de Arenaza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"26947","published-online":{"date-parts":[[2024,6,20]]},"container-title":["Archivos Peruanos de Cardiolog\u00eda y Cirug\u00eda Cardiovascular"],"original-title":[],"link":[{"URL":"https:\/\/apcyccv.org.pe\/index.php\/apccc\/article\/download\/388\/558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/apcyccv.org.pe\/index.php\/apccc\/article\/download\/388\/558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T05:02:43Z","timestamp":1724302963000},"score":1,"resource":{"primary":{"URL":"https:\/\/apcyccv.org.pe\/index.php\/apccc\/article\/view\/388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,20]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,6,24]]}},"URL":"https:\/\/doi.org\/10.47487\/apcyccv.v5i2.388","relation":{},"ISSN":["2708-7212"],"issn-type":[{"type":"electronic","value":"2708-7212"}],"subject":[],"published":{"date-parts":[[2024,6,20]]}}}