{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T22:04:36Z","timestamp":1782597876636,"version":"3.54.5"},"reference-count":21,"publisher":"Galenos Yayinevi","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turk J Surg"],"accepted":{"date-parts":[[2022,6,8]]},"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> Low-dose steroid therapy has been recommended in idiopathic granulomatous mastitis (IGM) in various studies in the literature, but the therapeutic minimum dose has not been determined yet. Furthermore, vitamin D deficiency, the effect of which is accepted in autoimmune diseases, has not been previously examined in IGM. The aim of our study was to evaluate the efficacy of lower dose steroid theraphy with adjustment of vitamin D replacement doses with measuring serum 25-hydroxyvitamin D levels in patients with idiopathic granulomatous mastitis (IGM).<\/jats:p>\n                    <jats:p><jats:bold>Material and Methods:<\/jats:bold> Vitamin D levels were evaluated in 30 IGM patients who applied to our clinic between 2017-2019. Vitamin D replacement was performed in patients with serum 25-hydroxyvitamin D level below 30 ng\/mL and prednisolone was given to all patients at a dose of 0.05-0.1 mg\/kg\/ day. Clinical recovery times of the patients were compared with the literature.<\/jats:p>\n                    <jats:p><jats:bold>Results:<\/jats:bold> Vitamin D replacement was given to 22 (73.33%) patients. Recovery time was shorter in patients receiving vitamin D replacement (7.62 \u00b1 2.38; 9.00 \u00b1 3.38; p= 0.680). Average recovery time was 8.00 \u00b1 2.68 weeks.<\/jats:p>\n                    <jats:p><jats:bold>Conclusion:<\/jats:bold> Treatment of IGM can be carried out with lower dose steroid therapy, leading to less complications and lower costs. Measuring serum 25-hydroxyvitamin D level and treating it with the appropriate dose may contribute to the healing process.<\/jats:p>","DOI":"10.47717\/turkjsurg.2022.5576","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:52:11Z","timestamp":1671540731000},"page":"250-254","source":"Crossref","is-referenced-by-count":4,"title":["The role of lower dose steroid therapy with vitamin D replacement in patients with idiopathic granulomatous mastitis"],"prefix":"10.47717","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6517-7948","authenticated-orcid":false,"given":"Tansu","family":"Alt\u0131nta\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2811","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"ref-1","doi-asserted-by":"crossref","unstructured":"Asoglu O, Ozmen V, Karanlik H, Tunaci M, Cabioglu N, Igci A, et al. Feasibility of surgical management in patients with granulomatous mastitis. Breast J 2005; 11:108-14. https:\/\/doi.org\/10.1111\/j.1075- 122X.2005.21576.x","DOI":"10.1111\/j.1075-122X.2005.21576.x"},{"key":"ref-2","doi-asserted-by":"crossref","unstructured":"Marriott DA, Russell J, Grebosky J, Wallace AM, Joste N, Royce ME. Idiopathic granuloma- tous lobular mastitis masquerading as a breast abscess and breast carcinoma. Am J Clin Oncol 2007; 30: 564-5. https:\/\/doi.org\/10.1097\/01.coc.0000184683.13865.df","DOI":"10.1097\/01.coc.0000184683.13865.df"},{"key":"ref-3","doi-asserted-by":"crossref","unstructured":"Kessler E, Wolloc Y. Granulomatous mastitis: A lesion clinically simulating carcinoma. Am J Clin Pathol 1972; 58: 642-6. https:\/\/doi. org\/10.1093\/ajcp\/58.6.642","DOI":"10.1093\/ajcp\/58.6.642"},{"key":"ref-4","doi-asserted-by":"crossref","unstructured":"Konan A, Kalyoncu U, Dogan I, Kili\u00e7 YA, Karako\u00e7 D, Akdogan A, et al. Combined long-term steroid and immunosuppressive treatment regimen in granulomatous mastitis. Breast Care 2012; 7(4): 297-301. https:\/\/doi.org\/10.1159\/000341388","DOI":"10.1159\/000341388"},{"key":"ref-5","doi-asserted-by":"crossref","unstructured":"Yukawa M, Watatani M, Isono S, Fujiwara Y, Tsujie M, Kitani K, et al. Management of granulomatous mastitis: A series of 13 patients who were evaluated for treatment without corticosteroids. Int Surg 2015; 100(5): 774-82 https:\/\/doi.org\/10.9738\/INTSURG-D-14-00231.1","DOI":"10.9738\/INTSURG-D-14-00231.1"},{"key":"ref-6","doi-asserted-by":"crossref","unstructured":"Yabanog\u0306lu H, C\u0327olakog\u0306lu T, Belli S, Atac\u0327 HO, Bolat FA et al. A comparative study of conservative versus surgical treatment protocols for 77 patients with idiopathic granulomatous mastitis. Breast J 2015; 21: 363-9. https:\/\/doi.org\/10.1111\/tbj.12415","DOI":"10.1111\/tbj.12415"},{"key":"ref-7","doi-asserted-by":"crossref","unstructured":"DeHertogh DA, Rossof AH, Harris AA, Economou SG. Predni- sone management of granulomatous mastitis. N Engl J Med 1980; 303: 799-800. https:\/\/doi.org\/10.1056\/NEJM198010023031406","DOI":"10.1056\/NEJM198010023031406"},{"key":"ref-8","doi-asserted-by":"crossref","unstructured":"Hovanessian Larsen LJ, Peyvandi B, Klipfel N, Grant E, Iyengar G. Granulomatous lobular mastitis: Imaging, diagnosis, and treatment. AJR Am J Roentgenol 2009; 193: 574-81. https:\/\/doi.org\/10.2214\/ AJR.08.1528","DOI":"10.2214\/AJR.08.1528"},{"key":"ref-9","doi-asserted-by":"crossref","unstructured":"Jorgensen MB, Nielsen DM. Diagnosis and treatment of granulo- matous mastitis. Am J Med 1992; 93: 97-101. https:\/\/doi. org\/10.1016\/0002-9343(92)90688-8","DOI":"10.1016\/0002-9343(92)90688-8"},{"key":"ref-10","doi-asserted-by":"crossref","unstructured":"Jinwoo Jeon, Kyunghee Lee, Yunyeong Kim, Yong Soon Chun, Heung Kyu Park. Retrospective analysis of idiopathic granulomatous mastitis: Its diagnosis and treatment. J Breast Dis 2017; 5(2): 82-8 https:\/\/ doi.org\/10.14449\/jbd.2017.5.2.82","DOI":"10.14449\/jbd.2017.5.2.82"},{"key":"ref-11","doi-asserted-by":"crossref","unstructured":"Cannell JJ, Grant WB, Holick MF. Vitamin D and inflammation. Dermatoendocrinol 2014; 6: e983401. https:\/\/doi.org\/10.4161\/19381980 .2014.983401","DOI":"10.4161\/19381980.2014.983401"},{"key":"ref-12","doi-asserted-by":"crossref","unstructured":"Jones BJ, Twomey PJ. Issues with vitamin D in routine clinical practice. Rheumatology 2008; 47: 1267-68. https:\/\/doi.org\/10.1093\/rheumatology\/ken301","DOI":"10.1093\/rheumatology\/ken301"},{"key":"ref-13","doi-asserted-by":"crossref","unstructured":"Guillot X, Semerano L, Saidenberg-Kermanac\u2019h N, Falgarone G, Boissier MC. Vitamin D and inflammation. Joint Bone Spine 2010; 77: 552-7. https:\/\/doi.org\/10.1016\/j.jbspin.2010.09.018","DOI":"10.1016\/j.jbspin.2010.09.018"},{"key":"ref-14","doi-asserted-by":"crossref","unstructured":"Zittermann A. Vitamin D in preventive medicine: Are we ignoring the evidence? Br J Nutr 2003; 89: 552-72. https:\/\/doi.org\/10.1079\/ BJN2003837","DOI":"10.1079\/BJN2003837"},{"key":"ref-15","doi-asserted-by":"crossref","unstructured":"Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357(3): 266-81. https:\/\/doi.org\/10.1056\/NEJMra070553","DOI":"10.1056\/NEJMra070553"},{"key":"ref-16","doi-asserted-by":"crossref","unstructured":"Norman AW, Bouillon R, Whiting SJ, Vieth R, Lips P. 13th workshop consensus for vitamin D nutritional guidelines. J Steroid Biochem Mol Biol 2007; 103(3-5): 204-5. https:\/\/doi.org\/10.1016\/j.jsbmb.2006.12.071","DOI":"10.1016\/j.jsbmb.2006.12.071"},{"key":"ref-17","doi-asserted-by":"crossref","unstructured":"Khurram M, Tariq M, Shahid P. Breast cancer with associated granulomatous axillary lymphadenitis: A diagnostic and clinical dilemma in regions with high prevalence of tuberculosis. Pathol Res Pract 2007; 203: 699-704 https:\/\/doi.org\/10.1016\/j.prp.2007.07.004","DOI":"10.1016\/j.prp.2007.07.004"},{"key":"ref-18","doi-asserted-by":"crossref","unstructured":"Boakes E, Woods A, Johnson N. Breast Infection: A Review of Diagnosis and Management Practices. Eur J Breast Health 2018; 14: 136-143 https:\/\/doi.org\/10.5152\/ejbh.2018.3871","DOI":"10.5152\/ejbh.2018.3871"},{"key":"ref-19","doi-asserted-by":"crossref","unstructured":"Sato N, Yamastita H, Kosaki N, Watanabe Y. Granulomatous mastitis diagnosed and followed up by fine needle aspiration cytology and successfully treated by corticosteroid therapy. Report of a case JPM\/J Surg 1996; 26: 730-3 https:\/\/doi.org\/10.1007\/BF00312095","DOI":"10.1007\/BF00312095"},{"key":"ref-20","doi-asserted-by":"crossref","unstructured":"Karanlik H, Ozgur I, Simsek S, Fathalizadeh A, Tukenmez M, Sahin D, et al. Can steroids plus surgery become a first-line treatment of idiopathic granulomatous mastitis? Breast Care (Basel) 2014; 9(5): 338-42. https:\/\/doi.org\/10.1159\/000366437","DOI":"10.1159\/000366437"},{"key":"ref-21","doi-asserted-by":"crossref","unstructured":"Cantorna MT. Vitamin D and autoimmunity: Is vitamin D status an environmental factor affecting autoimmune disease prevalence? Proc Soc Exp Biol Med 2000; 223: 230-3. https:\/\/doi.org\/10.1046\/ j.1525-1373.2000.22333.x","DOI":"10.1046\/j.1525-1373.2000.22333.x"}],"container-title":["Turkish Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/turkjsurg.com\/full-text-pdf\/1861\/eng","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/turkjsurg.com\/full-text-pdf\/1861\/eng","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T06:06:04Z","timestamp":1741068364000},"score":1,"resource":{"primary":{"URL":"https:\/\/turkjsurg.com\/articles\/doi\/turkjsurg.2022.5576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,9,1]]}},"URL":"https:\/\/doi.org\/10.47717\/turkjsurg.2022.5576","relation":{},"ISSN":["2564-6850","2564-7032"],"issn-type":[{"value":"2564-6850","type":"print"},{"value":"2564-7032","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,1]]}}}