{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:36:19Z","timestamp":1788921379119,"version":"build-2803163510"},"reference-count":22,"publisher":"Galenos Yayinevi","issue":"4","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turk J Surg"],"accepted":{"date-parts":[[2022,11,26]]},"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> Radical surgery for sigmoid colon cancer is commonly performed with complete mesocolic excision (CME) and apical lymph node dissection, reached by central vascular ligation (CVL) of the inferior mesenteric artery (IMA) and associated extended left colon resection. However, IMA branches can be ligated selectively according to tumor location with D3 lymph node dissection (LND), economic segmental colon resection and tumorspecific mesocolon excision (TSME) if IMA is skeletonized. This study aimed to compare left hemicolectomy with CME and CVL and segmental colon resection with selective vascular ligation (SVL) and D3 LND.<\/jats:p>\n                    <jats:p><jats:bold>Material and Methods:<\/jats:bold> Patients (n= 217) treated with D3 LND for adenocarcinoma of the sigmoid colon between January 2013 and January 2020 were included in the study. The approach to vessel ligation, colon resection and mesocolon excision was based on tumor location in the study group, while in the comparison group, left hemicolectomy with routine CVL was performed. Survival rates were estimated as the primary endpoints of the study. Long- and short-term surgery-related outcomes were evaluated as the secondary endpoints of the study.<\/jats:p>\n                    <jats:p><jats:bold>Results:<\/jats:bold> The studied approach to the IMA branch ligation was associated with a statistically significant decrease in intraoperative complication rates (2 vs 4, p= 0.024), operative procedure length (225.56 \u00b1 80.356 vs 330.69 \u00b1 175.488, p&lt; 0.001), and severe postoperative morbidity (6.2% vs 19.1%, p= 0.017). Meanwhile, the number of examined lymph nodes significantly increased (35.67 vs 26.69 per specimen, p&lt; 0.001). There were no statistically significant differences in survival rates.<\/jats:p>\n                    <jats:p><jats:bold>Conclusion:<\/jats:bold> Selective IMA branch ligation and TSME resulted in better intraoperative and postoperative outcomes with no difference in survival rates.<\/jats:p>","DOI":"10.47717\/turkjsurg.2022.5867","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T11:17:55Z","timestamp":1673349475000},"page":"382-390","source":"Crossref","is-referenced-by-count":8,"title":["Selective approach to arterial ligation in radical sigmoid colon cancer surgery with D3 lymph node dissection: A multicenter comparative study"],"prefix":"10.47717","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0283-2217","authenticated-orcid":false,"given":"Sergey","family":"Efetov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-3922","authenticated-orcid":false,"given":"Albina","family":"Zubayraeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4657-2998","authenticated-orcid":false,"given":"C\u00fcneyt","family":"Kayaalp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6996-2724","authenticated-orcid":false,"given":"Alisa","family":"Minenkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0159-9356","authenticated-orcid":false,"given":"Yusuf","family":"Ba\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2895-8478","authenticated-orcid":false,"given":"Aftandil","family":"Alekberzade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7134-6821","authenticated-orcid":false,"given":"Petr","family":"Tsarkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2811","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"ref-1","doi-asserted-by":"crossref","unstructured":"Hohenberger W, Weber K, Matzel K, Papadopoulos T, Merkel S. Standardized surgery for colonic cancer: Complete mesocolic excision and central ligation - technical notes and outcome. Colorectal Dis 2009; 11(4): 354-64. https:\/\/doi.org\/10.1111\/j.1463-1318.2008.01735.x","DOI":"10.1111\/j.1463-1318.2008.01735.x"},{"key":"ref-2","doi-asserted-by":"crossref","unstructured":"Hashiguchi Y, Muro K, Saito Y, Ito Y, Ajioka Y, Hamaguchi T, et al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer. Int J Clin Oncol 2020; 25(1): 1-42. https:\/\/doi.org\/10.1007\/s10147-019-01485-z","DOI":"10.1007\/s10147-019-01485-z"},{"key":"ref-3","doi-asserted-by":"crossref","unstructured":"S\u00f8ndenaa K, Quirke P, Hohenberger W, Sugihara K, Kobayashi H, Kessler H, et al. The rationale behind complete mesocolic excision (CME) and a central vascular ligation for colon cancer in open and laparoscopic surgery: Proceedings of a consensus conference. Int J Colorectal Dis 2014; 29(4): 419-28. https:\/\/doi.org\/10.1007\/s00384-013-1818-2","DOI":"10.1007\/s00384-013-1818-2"},{"key":"ref-4","doi-asserted-by":"crossref","unstructured":"Kobayashi M, Okamoto K, Namikawa T, Okabayashi T, Sakamoto J, Hanazaki K. Laparoscopic D3 lymph node dissection with preservation of the superior rectal artery for the treatment of proximal sigmoid and descending colon cancer. J Laparoendosc Adv Surg Tech A 2007; 17(4): 461-6. https:\/\/doi.org\/10.1089\/lap.2006.0053","DOI":"10.1089\/lap.2006.0053"},{"key":"ref-5","doi-asserted-by":"crossref","unstructured":"Kobayashi M, Okamoto K, Namikawa T, Okabayashi T, Araki K. Laparoscopic lymph node dissection around the inferior mesenteric artery for cancer in the lower sigmoid colon and rectum: Is D3 lymph node dissection with preservation of the left colic artery feasible? Surg Endosc 2006; 20(4): 563-9. https:\/\/doi.org\/10.1007\/s00464-005-0160-3","DOI":"10.1007\/s00464-005-0160-3"},{"key":"ref-6","doi-asserted-by":"crossref","unstructured":"Akagi T, Inomata M, Hara T, Mizusawa J, Katayama H, Shida D, et al. Clinical impact of D3 lymph node dissection with left colic artery (LCA) preservation compared to D3 without LCA preservation: Exploratory subgroup analysis of data from JCOG0404. Ann Gastroenterol Surg 2020; 4(2): 163-9. https:\/\/doi.org\/10.1002\/ags3.12318","DOI":"10.1002\/ags3.12318"},{"key":"ref-7","doi-asserted-by":"crossref","unstructured":"Japanese Society for Cancer of the Colon and Rectum. Japanese classification of colorectal, appendiceal, and anal carcinoma: The 3d English edition. J Anus Rectum Colon 2019; 3(4): 175-95. https:\/\/doi. org\/10.23922\/jarc.2019-018","DOI":"10.23922\/jarc.2019-018"},{"key":"ref-8","doi-asserted-by":"crossref","unstructured":"Kim BH, Kim JM, Kang GH, Chang HJ, Kang DW, Kim JH, et al. Standardized pathology report for colorectal cancer, 2nd edition. J Pathol Transl Med 2020; 54(1): 1-19. https:\/\/doi.org\/10.4132\/jptm.2019.09.28","DOI":"10.4132\/jptm.2019.09.28"},{"key":"ref-9","doi-asserted-by":"crossref","unstructured":"Nerad E, Lahaye MJ, Maas M, Nelemans P, Bakers FCH, Beets GL, et al. Diagnostic accuracy of CT for local staging of colon cancer: A systematic review and meta-analysis. AJR Am J Roentgenol 2016; 207(5): 984-95. https:\/\/doi.org\/10.2214\/AJR.15.15785","DOI":"10.2214\/AJR.15.15785"},{"key":"ref-10","doi-asserted-by":"crossref","unstructured":"Landen C, Dreu M, Weiglein A. The sigmoidea ima artery: A player in colonic ischemia? Clin Anat 2020; 33(6): 850-9. https:\/\/doi. org\/10.1002\/ca.23552","DOI":"10.1002\/ca.23552"},{"key":"ref-11","doi-asserted-by":"crossref","unstructured":"Dilday JC, Gilligan TC, Merritt CM, Nelson DW, Walker AS. Examining utility of routine splenic flexure mobilization during colectomy and impact on anastomotic complications. Am J Surg 2020; 219(6): 998- 1005. https:\/\/doi.org\/10.1016\/j.amjsurg.2019.07.030","DOI":"10.1016\/j.amjsurg.2019.07.030"},{"key":"ref-12","doi-asserted-by":"crossref","unstructured":"Kanemitsu Y, Hirai T, Komori K, Kato T. Survival benefit of high ligation of the inferior mesenteric artery in sigmoid colon or rectal cancer surgery. Br J Surg 2006; 93(5): 609-15. https:\/\/doi.org\/10.1002\/bjs.5327","DOI":"10.1002\/bjs.5327"},{"key":"ref-13","doi-asserted-by":"crossref","unstructured":"Rao X, Zhang J, Liu T, Wu Y, Jiang Y, Wang P, et al. Prognostic value of inferior mesenteric artery lymph node metastasis in cancer of the descending colon, sigmoid colon and rectum. Colorectal Dis 2018; 20(6): 135-42. https:\/\/doi.org\/10.1111\/codi.14105","DOI":"10.1111\/codi.14105"},{"key":"ref-14","doi-asserted-by":"crossref","unstructured":"Mari GM, Crippa J, Cocozza E, Berselli M, Livraghi L, Carzaniga P, et al. Low ligation of inferior mesenteric artery in laparoscopic anterior resection for rectal cancer reduces genitourinary dysfunction: Results from a randomized controlled trial (HIGHLOW Trial). Ann Surg 2019; 269(6): 1018-24. https:\/\/doi.org\/10.1097\/SLA.0000000000002947","DOI":"10.1097\/SLA.0000000000002947"},{"key":"ref-15","doi-asserted-by":"crossref","unstructured":"Wakahara T, Toyokawa A, Ashitani H, Tsuchida S, Hasegawa Y. Comparison of laparoscopic sigmoidectomy with and without preservation of the superior rectal artery: A single-institution retrospective study. Asian J Endosc Surg 2015; 8(1): 29-33. https:\/\/doi.org\/10.1111\/ases.12142","DOI":"10.1111\/ases.12142"},{"key":"ref-16","doi-asserted-by":"crossref","unstructured":"Yang Y, Wang G, He J, Zhang J, Xi J, Wang F. High tie versus low tie of the inferior mesenteric artery in colorectal cancer: A meta-analysis. Int J Surg 2018; 52: 20-4. https:\/\/doi.org\/10.1016\/j.ijsu.2017.12.030","DOI":"10.1016\/j.ijsu.2017.12.030"},{"key":"ref-17","doi-asserted-by":"crossref","unstructured":"Zeng J, Su G. High ligation of the inferior mesenteric artery during sigmoid colon and rectal cancer surgery increases the risk of anastomotic leakage: A meta-analysis. World J Surg Oncol 2018; 16(1): 157. https:\/\/doi.org\/10.1186\/s12957-018-1458-7","DOI":"10.1186\/s12957-018-1458-7"},{"key":"ref-18","doi-asserted-by":"crossref","unstructured":"Yada H, Sawai K, Taniguchi H, Hoshima M, Katoh M, Takahashi T. Analysis of vascular anatomy and lymph node metastases warrants radical segmental bowel resection for colon cancer. World J Surg 1997; 21(1): 109-15. https:\/\/doi.org\/10.1007\/s002689900202","DOI":"10.1007\/s002689900202"},{"key":"ref-19","doi-asserted-by":"crossref","unstructured":"Alici A, Kement M, Gezen C, Ak\u0131n T, Vural S, Okkabaz N, et al. Apical lymph nodes at the root of the inferior mesenteric artery in distal colorectal cancer: An analysis of the risk of tumor involvement and the impact of high ligation on anastomotic integrity. Tech Coloproctol 2010; 14(1): 1-8. https:\/\/doi.org\/10.1007\/s10151-009-0547-6","DOI":"10.1007\/s10151-009-0547-6"},{"key":"ref-20","doi-asserted-by":"crossref","unstructured":"Trepanier M, Erkan A, Kouyoumdjian A, Nassif G, Albert M, Monson J, et al. Examining the relationship between lymph node harvest and survival in patients undergoing colectomy for colon adenocarcinoma. Surgery 2019; 166(4): 639-47. https:\/\/doi.org\/10.1016\/j. surg.2019.03.027","DOI":"10.1016\/j.surg.2019.03.027"},{"key":"ref-21","doi-asserted-by":"crossref","unstructured":"Patroni A, Bonnet S, Bourillon C, Bruzzi M, Zinzindohou\u00e9 F, Chevallier JM, et al. Technical difficulties of left colic artery preservation during left colectomy for colon cancer. Surg Radiol Anat 2016; 38(4): 477-84. https:\/\/doi.org\/10.1007\/s00276-015-1583-8","DOI":"10.1007\/s00276-015-1583-8"},{"key":"ref-22","doi-asserted-by":"crossref","unstructured":"Tsarkov PV, Efetov SK, Zubayraeva AA, Puzakov KB, Oganyan NV. Surgeon\u2019s role in CT-based preoperative determination of inferior mesenteric artery anatomy in colorectal cancer treatment. Khirurgiia (Mosk). 2022;(9):40-49. English, Russian. doi: 10.17116\/hirurgia202209140. 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