{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:36:52Z","timestamp":1747226212209,"version":"3.40.5"},"reference-count":0,"publisher":"University of the Philippines Manila","issue":"17","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Philipp"],"abstract":"<jats:p>Nodular syphilis with a granulomatous inflammatory histopathologic pattern is an uncommon cutaneous presentation of secondary syphilis which could pose a diagnostic challenge for clinicians and pathologists alike.\r\nA 33-year-old male diagnosed with HIV presented with a 5-week history of asymptomatic generalized erythematous papules and nodules with overlying scales, with involvement of the palms and soles. Histopathologic examination of a nodule from the forearm revealed non-caseating granulomas in a background of a mixed cell inflammatory infiltrate composed of lymphocytes, epithelioid and foamy histiocytes, plasma cells, neutrophils, and multinucleated giant cells. Warthin-Starry Stain revealed spirochetal organisms, while Fite-Faraco and Periodic Acid-Schiff stains were negative for acid-fast bacilli and fungal elements, respectively. Rapid plasma reagin (RPR) was reactive (1:256). Patient was given a single dose of benzathine penicillin G 2.4 million units intramuscularly, with noted complete resolution of skin lesions as well as an 8-fold decrease in RPR titers.\r\nNodular lesions are an uncommon cutaneous manifestation of secondary syphilis, and the associated histopathologic finding of granulomatous inflammatory pattern is also unusual, posing a diagnostic challenge. With the increasing prevalence of syphilis, especially among HIV patients, dermatologists, dermatopathologists, internists, and infectious disease specialists should be aware of such presentations of syphilis.<\/jats:p>","DOI":"10.47895\/amp.v58i17.9040","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T08:35:30Z","timestamp":1727685330000},"source":"Crossref","is-referenced-by-count":0,"title":["A Peculiar Pattern: Nodular Secondary Syphilis with Granulomatous Dermatitis"],"prefix":"10.47895","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7717-4554","authenticated-orcid":false,"given":"Marian Rosel D.","family":"Villaverde, MD","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Paolo David S.","family":"Villena, MD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudine","family":"Yap Silva, MD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27557","published-online":{"date-parts":[[2024,9,30]]},"container-title":["Acta Medica Philippina"],"original-title":[],"link":[{"URL":"https:\/\/actamedicaphilippina.upm.edu.ph\/index.php\/acta\/article\/download\/9040\/5998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actamedicaphilippina.upm.edu.ph\/index.php\/acta\/article\/download\/9040\/5998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T08:35:31Z","timestamp":1727685331000},"score":1,"resource":{"primary":{"URL":"https:\/\/actamedicaphilippina.upm.edu.ph\/index.php\/acta\/article\/view\/9040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":0,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2024,9,30]]}},"URL":"https:\/\/doi.org\/10.47895\/amp.v58i17.9040","relation":{},"ISSN":["2094-9278","0001-6071"],"issn-type":[{"type":"electronic","value":"2094-9278"},{"type":"print","value":"0001-6071"}],"subject":[],"published":{"date-parts":[[2024,9,30]]}}}