{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:00:08Z","timestamp":1780473608680,"version":"3.54.1"},"reference-count":0,"publisher":"University of the Philippines Manila","issue":"10","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Philipp"],"abstract":"<jats:p>Background and Objective. Congenital and developmental disorders should be detected early to avoid complications such as disability and death. The Philippine clinical practice guidelines (CPG) were developed to guide healthcare professionals on screening for congenital and developmental disorders among apparently healthy neonates and children.\nMethods. Following the Grading of Recommendations\u00a0Assessment, Development and Evaluation (GRADE)\u00a0approach to CPG development recommended by the\u00a0Department of Health (DOH), the steering committee,\u00a0composed of clinical geneticists, developmental pediatricians,\u00a0family and community medicine physicians,\u00a0and ambulatory and community pediatricians, set the\u00a0objectives of the CPG and formulated clinical questions\u00a0in consultation with stakeholders. There were 15 priority\u00a0guideline questions that covered various disorders\u00a0including inborn errors of metabolism, critical congenital\u00a0heart disease, developmental delay, learning disabilities,\u00a0and autism. Evidence review experts systematically\u00a0reviewed existing clinical practice guidelines, appraised,\u00a0and summarized the evidence. A multisectoral panel\u00a0formulated recommendations through a formal consensus\u00a0based on the evidence summaries. The CPG was\u00a0externally reviewed prior to publication.\nResults. The CPG provides twenty (20) recommendations on fifteen (15) prioritized questions in the screening for certain congenital and developmental disorders. This CPG contains recommendations for the screening for critical congenital heart disease, thalassemia, Glucose-6-phosphate dehydrogenase (G6PD) deficiency, developmental delay, and autism spectrum disorder. Recommendations against routine screening of cystic fibrosis, sickle cell disease, methionine adenosyltransferase deficiency, tyrosinemia, long chain 3-hydroxy acyl CoA dehydrogenase deficiency\u00a0(LCHADD) and mitochondrial trifunctional protein deficiency\u00a0(MTPD), carnitine palmitoyl transferase types 1\u00a0and 2 (CPT1, CPT2) and glutaric aciduria type 2 (GA2),\u00a0biotidinase deficiency, beta-ketothiolase deficiency,\u00a0holocarboxylase synthetase deficiency, and isovaleric\u00a0acidemia were made.\nConclusion. The consensus panel recommended the screening of certain conditions, based on the available evidence, the burden of disease, the cost of the confirmatory testing, and its applicability to the population. Although this CPG intends to influence the direction of health policies for the general population, it should not be the sole basis for recreating or abolishing practices that aim to improve the health conditions of many Filipinos, particularly those part of the workforce.<\/jats:p>","DOI":"10.47895\/amp.v60i10.10675","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:00:52Z","timestamp":1780470052000},"source":"Crossref","is-referenced-by-count":0,"title":["Philippine Clinical Practice Guidelines for Periodic Health Examination: Screening for Congenital and Developmental Disorders"],"prefix":"10.47895","volume":"60","author":[{"given":"Mary Ann R.","family":"Abacan, MD, MSc, MHPEd","sequence":"first","affiliation":[{"name":"Division of Clinical and Metabolic Genetics, Department of Pediatrics, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2182-0468","authenticated-orcid":false,"given":"Kathryn R.","family":"Baltazar-Braganza, MD","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine and Surgery, University of Santo Tomas, Manila, Philippines"},{"name":"Section of Neurodevelopmental Pediatrics, Child Neuroscience Division, Philippine Children\u2019s Medical Center, Quezon City, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian Theodore G.","family":"Cabaluna, MD, Gdip (Epi) MSc","sequence":"additional","affiliation":[{"name":"Institute of Clinical Epidemiology, National Institutes of Health, University of the Philippines Manila, Manila, Philippines"},{"name":"Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella S.","family":"Ocampo, MD","sequence":"additional","affiliation":[{"name":"Department of Pediatrics - University of the Philippines-Philippine General Hospital"},{"name":"Philippine General Hospital, University of the Philippines Manila, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27557","published-online":{"date-parts":[[2026,5,30]]},"container-title":["Acta Medica Philippina"],"original-title":[],"link":[{"URL":"https:\/\/actamedicaphilippina.upm.edu.ph\/index.php\/acta\/article\/download\/10675\/7142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actamedicaphilippina.upm.edu.ph\/index.php\/acta\/article\/download\/10675\/7142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:00:53Z","timestamp":1780470053000},"score":1,"resource":{"primary":{"URL":"https:\/\/actamedicaphilippina.upm.edu.ph\/index.php\/acta\/article\/view\/10675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,30]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5,30]]}},"URL":"https:\/\/doi.org\/10.47895\/amp.v60i10.10675","relation":{},"ISSN":["2094-9278","0001-6071"],"issn-type":[{"value":"2094-9278","type":"electronic"},{"value":"0001-6071","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,30]]}}}