{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:24:48Z","timestamp":1780471488863,"version":"3.54.1"},"reference-count":0,"publisher":"University of the Philippines Manila","issue":"10","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Philipp"],"abstract":"<jats:p>Background and Objective. Renal, metabolic, nutritional, and endocrine disorders significantly affect Filipinos due\u00a0to the resulting mortality, cardiovascular outcomes, and negative impact on quality of life. Screening for these\u00a0disorders may lead to earlier detection and management of the disease, with subsequent improvement of clinical\u00a0outcomes if early therapeutic options are available. This must be balanced with potential harms resulting from\u00a0mislabeling and the adverse effects of treatment. The objective of this clinical practice guideline (CPG) is to provide\u00a0recommendations to optimize patient care on screening for renal, metabolic, nutritional, and endocrine disorders\u00a0among asymptomatic, apparently healthy Filipinos.\nMethods. We followed the Grading of Recommendations\u00a0Assessment, Development and Evaluation (GRADE)\u00a0approach to CPG development recommended in the\u00a0Department of Health Manual. The process included 1)\u00a0generation of critical questions and critical outcomes, 2)\u00a0retrieval of current evidence, 3) synthesis and assessment\u00a0of the evidence base for these critical questions, 4)\u00a0formulation of draft recommendations, 5) convening\u00a0of a multisectoral\u00a0stakeholder panel that evaluated\u00a0the evidence base and considered feasibility, values,\u00a0and preferences in formulating recommendations, and\u00a06) planning for dissemination, implementation, impact\u00a0evaluation, and updating. We performed a systematic\u00a0synthesis of evidence to address screening for high\u00a0climacteric syndrome, hypocalcemia or hypercalcemia,\u00a0prediabetes, chronic kidney disease, hyperuricemia,\u00a0malnutrition, nutritional anemia, among asymptomatic,\u00a0apparently healthy adult Filipinos, and sexual maturity\u00a0among asymptomatic, apparently healthy adolescent\u00a0Filipinos.\nResults. After the presentation of the evidence synthesis and deliberation of the consensus panelists, this CPG provides 18 recommendation statements for the eight conditions. These statement recommendations serve as guides for the primary care physicians in their screening\u00a0 for the identified renal, metabolic, nutritional, and\u00a0endocrine disorders. The CPG recommends AGAINST\u00a0screening for high climacteric syndrome among\u00a0asymptomatic, apparently healthy women aged 45\u201355\u00a0years using hormonal tests. Moreover, the guideline\u00a0DOES NOT recommend the use of serum calcium,\u00a0electrocardiogram, or bone mineral density in screening\u00a0for hypocalcemia or hypercalcemia; estimated glomerular\u00a0filtration rate, urine albumin concentration, urine\u00a0albumin-creatinine ratio, and kidney ultrasonography\u00a0in screening for chronic kidney disease; mid-upper\u00a0arm circumference in screening for malnutrition; and,\u00a0serum uric acid in screening for hyperuricemia for\u00a0apparently healthy, asymptomatic adults. Routine\u00a0assessment for sexual maturity among asymptomatic\u00a0adolescents is also NOT recommended. However, the\u00a0guideline recommends using fasting plasma glucose and\u00a0hemoglobin A1C in screening for prediabetes and type\u00a02 diabetes mellitus; waist circumference, waist-hip ratio,\u00a0and body mass index in screening for malnutrition; and\u00a0hemoglobin and red blood cell parameters in screening\u00a0for nutritional anemia.\nConclusion. The CPG for the Periodic Health Examination,\u00a0a joint project of the Department of Health and\u00a0the National Institutes of Health, addressed selected\u00a0renal, metabolic, nutritional, and endocrine conditions\u00a0and provided recommendations for their screening. The\u00a0statements are made to guide the primary care physicians\u00a0in the screening of identified renal, metabolic, nutritional,\u00a0and endocrine disorders. These recommendations will be\u00a0updated after three years or until new evidence arises.<\/jats:p>","DOI":"10.47895\/amp.v60i10.11674","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:56:53Z","timestamp":1780469813000},"source":"Crossref","is-referenced-by-count":0,"title":["Philippine Clinical Practice Guidelines for Periodic Health Examination: Screening for Renal, Metabolic, Nutritional, and Endocrine Disorders"],"prefix":"10.47895","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0232-890X","authenticated-orcid":false,"given":"Elizabeth","family":"Paz-Pacheco, MD, PhD","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8432-486X","authenticated-orcid":false,"given":"Raymond V.","family":"Oliva, MD","sequence":"additional","affiliation":[{"name":"Division of Hypertension, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8999-4010","authenticated-orcid":false,"given":"Cecilia S.","family":"Acuin, MD, PhD","sequence":"additional","affiliation":[{"name":"Institute of Human Nutrition and Food, University of the Philippines Los Ba\u00f1os, Laguna, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2904-4088","authenticated-orcid":false,"given":"Rey Jaime M.","family":"Tan, MD","sequence":"additional","affiliation":[{"name":"Philippine General Hospital, University of the Philippines Manila, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim Paulo D.","family":"Sarsagat, MD","sequence":"additional","affiliation":[{"name":"Allied Care Experts Medical Center Palawan, Palawan, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27557","published-online":{"date-parts":[[2026,5,30]]},"container-title":["Acta Medica Philippina"],"original-title":[],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:56:54Z","timestamp":1780469814000},"score":1,"resource":{"primary":{"URL":"https:\/\/actamedicaphilippina.upm.edu.ph\/index.php\/acta\/article\/view\/11674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,30]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5,30]]}},"URL":"https:\/\/doi.org\/10.47895\/amp.v60i10.11674","relation":{},"ISSN":["2094-9278","0001-6071"],"issn-type":[{"value":"2094-9278","type":"electronic"},{"value":"0001-6071","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,30]]}}}