{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:20:40Z","timestamp":1780471240569,"version":"3.54.1"},"reference-count":0,"publisher":"University of the Philippines Manila","issue":"10","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Philipp"],"abstract":"<jats:p>Background and Objective. Cancer is among the leading causes of death in the Philippines, with an age-standardized\u00a0mortality rate of 100 deaths per 100,000 persons. Despite the high incidence and mortality in the country, the\u00a0Philippines has yet to implement a national early detection or screening program for cancers. The goal of these clinical\u00a0practice guidelines (CPGs) is to provide evidence-based recommendations on screening for specific types of cancer:\u00a0retinoblastoma, nasopharyngeal cancer, liver cancer, cervical cancer, oral cancer, colorectal cancer, breast cancer,\u00a0prostate cancer, lung cancer, and gastric cancer.\nMethods. The Grading of Recommendations Assessment,\u00a0Development and Evaluation (GRADE) approach\u00a0to CPG development recommended in the Department\u00a0of Health Manual was followed. There were 10 clinical\u00a0questions covered in this CPG, of which 9 questions\u00a0involved asymptomatic or apparently healthy adults, while\u00a01 question involved early detection of retinoblastoma\u00a0among children. The evidence of net benefit or harm\u00a0of cancer screening was obtained through a systematic\u00a0literature search from database inception up to August\u00a02021. Additional information on cost-effectiveness,\u00a0patient values and preferences, acceptability, feasibility\u00a0of screening, and its impact on equity was also obtained.\u00a0The final recommendations were made through\u00a0consensus by a panel of representatives from multiple\u00a0stakeholder groups.\nResults. There were 20 recommendations formulated. Strong recommendations were given to screen the following: patients at risk for hepatocellular carcinoma using ultrasound with alpha-fetoprotein (AFP); women aged 30 to 65 years for cervical cancer with cervical cytology alone, or high-risk Human papillomavirus (HPV)\u00a0 testing alone, or visual inspection with acetic acid as\u00a0alternative to Pap smear; adults aged 35 and older who\u00a0are smokers or alcohol drinkers for oral cancer using\u00a0visual examination, and women 50 to 69 years for breast\u00a0cancer using mammography and biennial clinical breast\u00a0examination. However, strong recommendations were\u00a0made AGAINST screening for cervical cancer among\u00a0women aged 21 to 29 years, and AGAINST screening\u00a0for cervical cancer with high-risk HPV testing in combination\u00a0with cytology (co-testing).\nConclusion. Through a comprehensive and systematic\u00a0search of the best available evidence, the Neoplastic\u00a0Diseases Task Force developed 20 recommendations\u00a0on screening and risk factor assessment for 10 specific\u00a0questions on neoplastic diseases. These recommendations\u00a0serve as guidance on screening neoplastic diseases\u00a0at the primary care level.<\/jats:p>","DOI":"10.47895\/amp.v60i10.13373","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:48:45Z","timestamp":1780469325000},"source":"Crossref","is-referenced-by-count":0,"title":["Philippine Clinical Practice Guidelines for Periodic Health Examination: Screening for Neoplastic Diseases"],"prefix":"10.47895","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5373-1750","authenticated-orcid":false,"given":"Beatrice J.","family":"Tiangco, MD","sequence":"first","affiliation":[{"name":"Institute of Clinical Epidemiology, National Institutes of Health, University of the Philippines Manila, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4382-4793","authenticated-orcid":false,"given":"Aldrich Ivan Lois D.","family":"Burog, MD, MSc","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Meredith","family":"Garcia-Trinidad, MD","sequence":"additional","affiliation":[{"name":"Section of Medical Oncology, Dagupan Doctors Villaflor Memorial Hospital, Pangasinan, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ondinee","family":"Manalo-Igot, MD","sequence":"additional","affiliation":[{"name":"Asian Hospital and Medical Center, Muntinlupa, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6235-0426","authenticated-orcid":false,"given":"Aldrin B.","family":"Loyola, MD","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger N.","family":"Velasco, Jr. MD","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Department, Lung Center of the Philippines, Quezon City, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7477-0251","authenticated-orcid":false,"given":"Myzelle Anne J.","family":"Infantado-Alejandro, PTRP, MSc","sequence":"additional","affiliation":[{"name":"De La Salle Medical and Health Sciences Institute, Cavite, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6390-0917","authenticated-orcid":false,"given":"Kenneth G.","family":"Samala, MD","sequence":"additional","affiliation":[{"name":"Manila Med \u2013 Medical Center Manila, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jezreline Marie I.","family":"Cacanindin-Rimando, MD","sequence":"additional","affiliation":[{"name":"Section of Medical Oncology, Saint Louis University Sacred Heart Medical Center, Baguio City, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7885-2452","authenticated-orcid":false,"given":"Howell Henrian G.","family":"Bayona, RSLP, MSc","sequence":"additional","affiliation":[{"name":"Institute of Clinical Epidemiology, National Institutes of Health, University of the Philippines Manila, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina Antonina S.","family":"Eubanas, MD","sequence":"additional","affiliation":[{"name":"Healthway Daniel Mercado Medical Center, Batangas, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma. Pamela D.","family":"Patdu, MD, MCM(MO)","sequence":"additional","affiliation":[{"name":"Philippine Society of Medical Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27557","published-online":{"date-parts":[[2026,5,30]]},"container-title":["Acta Medica Philippina"],"original-title":[],"link":[{"URL":"https:\/\/actamedicaphilippina.upm.edu.ph\/index.php\/acta\/article\/download\/13373\/7146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actamedicaphilippina.upm.edu.ph\/index.php\/acta\/article\/download\/13373\/7146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:48:45Z","timestamp":1780469325000},"score":1,"resource":{"primary":{"URL":"https:\/\/actamedicaphilippina.upm.edu.ph\/index.php\/acta\/article\/view\/13373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,30]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5,30]]}},"URL":"https:\/\/doi.org\/10.47895\/amp.v60i10.13373","relation":{},"ISSN":["2094-9278","0001-6071"],"issn-type":[{"value":"2094-9278","type":"electronic"},{"value":"0001-6071","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,30]]}}}