{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:52:48Z","timestamp":1792129968233,"version":"4.4.0"},"reference-count":34,"publisher":"Korean Encephalitis and Neuroinflammation Society","issue":"4","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Advanced Neural Technologies"},{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["0620182930"],"award-info":[{"award-number":["0620182930"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["encephalitisjournal.org"],"crossmark-restriction":true},"short-container-title":["encephalitis"],"published-print":{"date-parts":[[2026,10,10]]},"abstract":"<jats:p>PurposeThe structural integrity of white matter in the human brain, including myelination, is important not only for brain pathology but also for cognitive functions, including social behavior. Here, we investigated the relationship between myelination abnormalities and antisocial maltreating behavior in mice.MethodsThe demyelination model was generated by feeding cuprizone to C57BL\/6 mice. Luxol fast blue staining was performed to visualize myelin. The demyelination model was subjected to a maltreating behavioral task. Oxytocin (OXY), haloperidol (HAL), and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) were used.ResultsThe demyelination model mice showed a higher number of nose-pokes than the control. OXY or 8-OH-DPAT treatment reduced the high nose-poking number of the demyelination model mice. HAL did not largely affect the number of nose-pokes of the demyelination model mice.ConclusionDemyelination appears to be closely related to antisocial maltreating behavior. Our maltreating-behavior assay system is a good animal system for investigating brain disorders involving antisocial or psychotic behavior.<\/jats:p>","DOI":"10.47936\/encephalitis.2026.00052","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:18:25Z","timestamp":1786612705000},"page":"103-108","update-policy":"https:\/\/doi.org\/10.47936\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cuprizone-induced demyelination model mice exhibit antisocial maltreating behavior: an experimental animal 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