{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:49:53Z","timestamp":1766137793423},"reference-count":0,"publisher":"Care Comm","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ceska Gynekol"],"published-print":{"date-parts":[[2021,8,30]]},"abstract":"<jats:p>Summary:  Introduction: Preeclampsia is a\u202flife-threatening condition for the mother and foetus. Globally, it is diagnosed in 10\u202fmil. women every year, which accounts for 3% to 8% of all pregnancies. Currently there is no proven effective treatment for preeclampsia. The aforesaid text actualises the issue of predicting this complication. To determine the prognostic significance of matrix metalloproteinases-2\u202fand -9 levels as early markers of preeclampsia, the present prospective study was conducted. Materials and methods: The levels of matrix metalloproteinases-2\u202f and -9\u202f were assessed in 72\u202f patients. Thirty-four\u202f of them subsequently developed preeclampsia during pregnancy (20\u202fpatients with moderate preeclampsia, 14\u202fpatients with severe preeclampsia), and constituted the basic group; 38\u202fpatients made up the control group. Results: In pregnant women with the subsequent development of preeclampsia, the level of matrix metalloproteinase-2\u202fat 11\u201313\u202fweeks of gestation was 155\u202f\u00b1\u202f73.4\u202fng\/mL and significantly exceeded its level in pregnant women without hypertensive disorders \u2013 75.0\u202f\u00b1\u202f32.8\u202fng\/mL. The study conducted demonstrates a\u202fsignificantly lower concentration of matrix metalloproteinase-9\u202fin pregnant women with preeclampsia compared to the control \u2013 749\u202f\u00b1\u202f296\u202fng\/mL and 1,667\u202f\u00b1\u202f552\u202fng\/mL (P\u202f&lt;\u202f0.001). The performed research figures that in the first trimester, the cut-off value of matrix metalloproteinase-2\u202ffor predicting the development of preeclampsia is\u202f\u2265\u202f102\u202fng\/mL (sensitivity 88.24% and specificity 82.76%). For matrix metalloproteinase-9, a\u202flevel of\u202f\u2264\u202f980\u202fng\/mL in the first trimester predicts the development of preeclampsia with a\u202fsensitivity of 85.29% and a\u202fspecificity of 84.48%. Conclusion: The study established the cut-off values of matrix metalloproteinases-2\u202fand -9\u202ffor predicting the development of preeclampsia in the first trimester.<\/jats:p>","DOI":"10.48095\/cccg2021228","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T03:27:21Z","timestamp":1631590041000},"page":"228-235","source":"Crossref","is-referenced-by-count":6,"title":["Matrix metalloproteinases MMP-2 and MMP-9 as markers for the prediction of preeclampsia in the first trimester"],"prefix":"10.48095","volume":"86","author":[{"name":"Department of Obstetrics, Gynecology and Perinatology, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Timokhina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vadim","family":"Zinin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Ignatko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sapyat","family":"Ibragimova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa","family":"Belotserkovtseva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksander","family":"Strizhakov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"28151","published-online":{"date-parts":[[2021,8,30]]},"container-title":["\u010cesk\u00e1 gynekologie"],"original-title":["Matrix metalloproteinases MMP-2 and MMP-9 as markers for the prediction of preeclampsia in the first trimester"],"deposited":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T03:27:22Z","timestamp":1631590042000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cs-gynekologie.cz\/en\/journals\/czech-gynaecology\/2021-4-6\/matrix-metalloproteinases-mmp-2-and-mmp-9-as-markers-for-the-prediction-of-preeclampsia-in-the-first-trimester-127956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,30]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,8,30]]},"published-print":{"date-parts":[[2021,8,30]]}},"URL":"https:\/\/doi.org\/10.48095\/cccg2021228","relation":{},"ISSN":["1210-7832","1805-4455"],"issn-type":[{"type":"print","value":"1210-7832"},{"type":"electronic","value":"1805-4455"}],"subject":[],"published":{"date-parts":[[2021,8,30]]}}}