{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T22:23:51Z","timestamp":1723069431288},"reference-count":0,"publisher":"Care Comm","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ceska Gynekol"],"published-print":{"date-parts":[[2023,12,20]]},"abstract":"<jats:p>Objective: In the Czech Republic, it is possible, to carry out Medical Termination of Pregnancy (MToP) in the 1st trimester up until the 49th day of secondary amenorrhea. The aim of the study is to analyse the significance of serum\/urine human chorionic gonadotropin (hCG) assessment and ultrasound (US) examination in pregnancy diagnosis and MToP follow-up. Methods: In 2017\u20132018, MToP was carried out in a total of 109 women by administering a combination of mifepristone (600 mg orally) and misoprostol (400 mcg orally). Serum\/urine (LSUP \u2013 low sensitivity urine pregnancy test) hCG assessment and US examination were performed at pregnancy diagnosis and MToP follow-up. Results: At pregnancy diagnosis, there was a positive and medium strong correlation between serum hCG and size of the gestational sac \u2013 GS (R = 0.711; P &lt; 0.0001) and crown-rump length of the embryo \u2013 CRL (R = 0.605; P &lt; 0.0001). Gestational age was 42\u201349 days (average 45.6, median 45 days), the women were 16\u201344 years of age (average 29.4, median 29 years). In MToP follow-up, serum hCG level was &gt; 1,000 IU\/L in 13.8% of women (15\/109) and a positive LSUP test in 17.4% (20\/109). US examination diagnosed ongoing pregnancy in five women and missed abortion in one woman (serum hCG was always &gt; 1,000 IU\/L and LSUP test was always positive). In 5.5% of women (6\/109), a subsequent surgical intervention was carried out including those with ongoing pregnancy (N = 5); missed abortion (N = 1) was treated by additional misoprostol, where surgical intervention was not necessary. Conclusion: At pregnancy diagnosis, there is a positive and medium strong correlation between serum hCG and CRL. In MToP follow-up, a negative LSUP test enables reliable exclusion of ongoing pregnancy and missed abortion. In case of a positive LSUP test, US examination should be performed; however, surgical intervention should not be indicated solely on the basis of uterine cavity dilatation.   Key words: medical termination of pregnancy \u2013 1st trimester \u2013 human chorionic gonadotropin \u2013 ultrasound<\/jats:p>","DOI":"10.48095\/cccg2023420","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T15:35:52Z","timestamp":1704296152000},"page":"420-427","source":"Crossref","is-referenced-by-count":0,"title":["Medical Termination of Pregnancy (MToP) in the 1st trimester \u2013 the role of human chorionic gonadotropin and ultrasound in pregnancy diagnosis and MToP follow-up"],"prefix":"10.48095","volume":"88","author":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Palacky University and University Hospital Olomouc, Czech Republic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladim\u00edr","family":"Dvo\u0159\u00e1k","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Slunsk\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Tozzi Mad\u011brkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate\u0159ina","family":"Langov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladim\u00edra","family":"Kroutilov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radovan","family":"Pilka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"\u013dubu\u0161k\u00fd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"28151","published-online":{"date-parts":[[2023,12,20]]},"container-title":["\u010cesk\u00e1 gynekologie"],"original-title":["Medical Termination of Pregnancy (MToP) in the 1st trimester \u2013 the role of human chorionic gonadotropin and ultrasound in pregnancy diagnosis and MToP follow-up"],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T15:35:57Z","timestamp":1704296157000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cs-gynekologie.cz\/en\/journals\/czech-gynaecology\/2023-6-2\/medical-termination-of-pregnancy-mtop-in-the-1st-trimester-the-role-of-human-chorionic-gonadotropin-and-ultrasound-in-pregnancy-diagnosis-and-mtop-follow-up-136011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,20]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,12,20]]},"published-print":{"date-parts":[[2023,12,20]]}},"URL":"https:\/\/doi.org\/10.48095\/cccg2023420","relation":{},"ISSN":["1210-7832","1805-4455"],"issn-type":[{"type":"print","value":"1210-7832"},{"type":"electronic","value":"1805-4455"}],"subject":[],"published":{"date-parts":[[2023,12,20]]}}}