{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T22:24:22Z","timestamp":1723069462070},"reference-count":0,"publisher":"Care Comm","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ceska Gynekol"],"published-print":{"date-parts":[[2024,4,22]]},"abstract":"<jats:p>Objective: To compare cervical stroma in advanced cervical cancer with the control group; to compare, in the pre-treatment period, hemogram parameters in patients with advanced cervical cancer with the same parameters as the control group; and to verify if there is an association of stromal markers with prognostic factors in cervical cancer. Materials and methods: We prospectively evaluated 16 patients diagnosed with advanced invasive cervical cancer. A control group of 22 patients was used (uterine leiomyoma). Immunohistochemistry was performed to verify the stromal immunostaining of alpha-smooth muscle actin (SMA) and fibroblast activation protein alpha (FAP). Immunostainings and hemogram parameters were compared using Fisher's exact and Mann-Whitney Test, respectively. Results: Strong FAP immunostaining was more frequent in patients with cervical cancer when compared with patients with leiomyoma (P = 0.0002). Regarding SMA, strong immunostaining was also found more in the group of cancer patients compared to the control group (P &lt; 0.00001). The neutrophil-lymphocyte ratio (NLR) values were higher in the cancer patient group compared to the control group (P = 0.0019). There was no association of the parameters studied with prognostic factors. Conclusions: Strong FAP and SMA immunostaining was found more in patients with cervical cancer when compared to the control group. NLR values were also higher in cervical cancer.   Key words: uterine cervical neoplasms \u2013 alpha-smooth muscle actin \u2013 fibroblast activation protein alpha \u2013 blood cell count<\/jats:p>","DOI":"10.48095\/cccg202495","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T08:43:02Z","timestamp":1715330582000},"page":"95-101","source":"Crossref","is-referenced-by-count":0,"title":["Peritumoral stroma and systemic inflammatory response in cervical cancer"],"prefix":"10.48095","volume":"89","author":[{"name":"Service of Radiotherapy, Federal University of Tri\u00e2ngulo Mineiro, Uberaba, Brazil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio","family":"Santana Otano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anelise","family":"Mendes Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Beatriz","family":"Ferreira Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica","family":"Souto Morlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliangela","family":"de Castro C\u00f4bo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina","family":"Mac\u00eado Barcelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adilha","family":"Misson Rua Micheletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Millena","family":"Prata Jammal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eddie Fernando","family":"Candido Murta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosekeila","family":"Sim\u00f5es Nomelini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"28151","published-online":{"date-parts":[[2024,4,23]]},"container-title":["\u010cesk\u00e1 gynekologie"],"original-title":["Peritumoral stroma and systemic inflammatory response in cervical cancer"],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T08:43:08Z","timestamp":1715330588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cs-gynekologie.cz\/en\/journals\/czech-gynaecology\/2024-2-1\/peritumoral-stroma-and-systemic-inflammatory-response-in-cervical-cancer-137202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,4,23]]},"published-print":{"date-parts":[[2024,4,22]]}},"URL":"https:\/\/doi.org\/10.48095\/cccg202495","relation":{},"ISSN":["1210-7832","1805-4455"],"issn-type":[{"type":"print","value":"1210-7832"},{"type":"electronic","value":"1805-4455"}],"subject":[],"published":{"date-parts":[[2024,4,22]]}}}