{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:33:42Z","timestamp":1780922022099,"version":"3.54.1"},"reference-count":0,"publisher":"Care Comm","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ceska Gynekol"],"published-print":{"date-parts":[[2025,10,30]]},"abstract":"<jats:p>Fetal growth restriction is a condition in which the fetus fails to reach its genetically determined growth potential, most often as a result of impaired placental function. The late-onset form, which develops after 32 weeks of gestation, poses a significant diagnostic challenge due to its subtle clinical and sonographic manifestations. Placental insufficiency is usually associated with pregnancies that meet the established diagnostic criteria for fetal growth restriction. However, there is increasing evidence to suggest that even fetuses with an estimated weight appropriate for gestational age may be affected by a subclinical form of this condition. Typical features of advanced placental dysfunction include abnormal Doppler flow patterns, a slowed fetal growth trajectory, altered levels of maternal serum biomarkers, and specific histopathological findings in the placenta. Despite advances in prenatal diagnostics, there is still no reliable tool capable of identifying pregnancies complicated by placental insufficiency in a timely manner, especially in cases without overt fetal growth deviation. This diagnostic gap limits our ability to identify fetuses at increased risk of adverse perinatal outcomes. \n\nKey words: late-onset fetal growth restriction \u2013 placental insufficiency \u2013 Doppler ultrasound \u2013 biochemical markers \u2013 placental histopathology<\/jats:p>","DOI":"10.48095\/cccg2025398","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T12:26:53Z","timestamp":1761913613000},"page":"398-406","source":"Crossref","is-referenced-by-count":1,"title":["Placental insufficiency and late-onset growth restriction in fetuses appropriate for gestational age"],"prefix":"10.48095","volume":"90","author":[{"name":"Department of Obstetrics and Gynecology, Medical Faculty of Masaryk University and University Hospital Brno, Czech Republic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lud\u011bk","family":"Kostka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Je\u017eov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Mikulenkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Jouzov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luk\u00e1\u0161","family":"Hruban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"28151","published-online":{"date-parts":[[2025,10,31]]},"container-title":["\u010cesk\u00e1 gynekologie"],"original-title":["Placent\u00e1rn\u00ed insuficience a pozdn\u00ed r\u016fstov\u00e1 restrikce ve skupin\u011b plod\u016f s adekv\u00e1tn\u00ed velikost\u00ed pro dan\u00e9 gesta\u010dn\u00ed st\u00e1\u0159\u00ed"],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T12:26:55Z","timestamp":1761913615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cs-gynekologie.cz\/en\/journals\/czech-gynaecology\/2025-5-5\/placental-insufficiency-and-late-onset-growth-restriction-in-fetuses-appropriate-for-gestational-age-141994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,10,31]]},"published-print":{"date-parts":[[2025,10,30]]}},"URL":"https:\/\/doi.org\/10.48095\/cccg2025398","relation":{},"ISSN":["1210-7832","1805-4455"],"issn-type":[{"value":"1210-7832","type":"print"},{"value":"1805-4455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,30]]}}}