{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T12:30:58Z","timestamp":1761913858118,"version":"build-2065373602"},"reference-count":0,"publisher":"Care Comm","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ceska Gynekol"],"published-print":{"date-parts":[[2025,10,30]]},"abstract":"<jats:p>Angiosarcoma (AS) is a rare malignant tumor originating from the endothelial cells of blood or lymphatic vessels. It is characterized by an aggressive course with a high risk of generalization. The most frequent sites of metastasis include the skin, soft tissues, breasts, liver, and heart. Clinical symptoms vary depending on the site of origin. The most common include erythema, skin efflorescence, swelling, and tenderness. Diagnosis of AS is established based on histopathological examination with evidence of atypical endothelial cells and vascular structures. Imaging methods are used as supplementary examinations and help in determining the location and extent of the tumor. In this publication, we focus on the secondary type of angiosarcoma, which has been increasingly described in recent years in the irradiated breast area after breast-conserving surgery. We describe three case reports of patients comprehensively treated at our institution. A relatively long remission, spanning several years, is typical. The essential basis of AS treatment is surgical removal of the tumor with intact resection margins. Due to the size of the defect after resection, simple suturing of the skin cover is often insufficient, and collaboration with a plastic surgeon is necessary for the reconstruction of the resulting defect. Professional literature does not unequivocally state the sufficient width of the healthy tissue margin during resection. The benefit of adjuvant chemotherapy or radiotherapy is debatable. Prognosis is generally poor due to insufficient sensitivity to non-surgical treatment modalities and the speed of metastasis. \n\nKey words: radiation-induced angiosarcoma of the breast \u2013 secondary breast angiosarcoma \u2013 radiotherapy \u2013 breast cancer \u2013 radiotherapy complications \u2013 soft tissue sarcoma \u2013 malignant vascular tumor \u2013 post-radiation sarcoma \u2013 angiosarcoma diagnosis \u2013 angiosarcoma treatment \u2013 prognosis \u2013 breast resection<\/jats:p>","DOI":"10.48095\/cccg2025407","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T12:26:53Z","timestamp":1761913613000},"page":"407-412","source":"Crossref","is-referenced-by-count":0,"title":["Radiation-induced angiosarcoma of the breast \u2013 experience from clinical practice"],"prefix":"10.48095","volume":"90","author":[{"name":"Department of Obstetrics and Gynecology, Medical Faculty of Masaryk University and University Hospital Brno, Czech Republic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Frydov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Meixnerov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Kobl\u00ed\u017ekov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"Bran\u010d\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Rotschein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubo\u0161","family":"Min\u00e1\u0159","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"28151","published-online":{"date-parts":[[2025,10,31]]},"container-title":["\u010cesk\u00e1 gynekologie"],"original-title":["Radia\u010dn\u011b indukovan\u00fd angiosarkom prsu \u2013 zku\u0161enosti z klinick\u00e9 praxe"],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T12:26:55Z","timestamp":1761913615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cs-gynekologie.cz\/en\/journals\/czech-gynaecology\/2025-5-5\/radiation-induced-angiosarcoma-of-the-breast-experience-from-clinical-practice-141995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,10,31]]},"published-print":{"date-parts":[[2025,10,30]]}},"URL":"https:\/\/doi.org\/10.48095\/cccg2025407","relation":{},"ISSN":["1210-7832","1805-4455"],"issn-type":[{"value":"1210-7832","type":"print"},{"value":"1805-4455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,30]]}}}