{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:08:01Z","timestamp":1785420481959,"version":"3.56.0"},"reference-count":0,"publisher":"Care Comm","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ceska Gynekol"],"published-print":{"date-parts":[[2026,6,26]]},"abstract":"<jats:p>Human reproductive efficiency is relatively low compared with that of other mammals, a phenomenon that may be linked to evolutionary factors. One of the principal biological contributors is the high incidence of aneuploidy in oocytes and embryos, a risk that increases markedly with advancing maternal age. Successful implantation requires not only a genetically normal embryo, but also a receptive endometrium and a functional feto-maternal dialogue. Nevertheless, even after the transfer of a euploid embryo, implantation occurs in only 60\u201370% of cases, underscoring the importance of the uterine environment for successful embryo attachment. A key element in the implantation process is the immunological balance at the feto-maternal interface. Uterine natural killer (uNK) cells constitute the dominant lymphocyte population within the decidua and play essential roles in implantation, placentation, and fetal immunotolerance. Their function is mediated, among other mechanisms, by interactions with trophoblast cells through killer-cell immunoglobulin-like (KIR) receptors and human leukocyte antigen C (HLA-C) antigens. Imbalances in these interactions can contribute to pregnancy pathologies such as implantation failure, miscarriage, preeclampsia, and fetal growth restriction. Although current diagnostic methods enable assessment of immunological conditions in reproductive tissues, interpreting these findings in the context of fertility or infertility remains challenging. Emerging research directions include the application of molecular genetics and detailed characterization of distinct NK cell subpopulations. Despite recent advances, therapeutic modulation of immunological mechanisms in reproduction remains limited and warrants further investigation. \n\nKey words: uterine NK cells \u2013 pregnancy loss \u2013 KIR receptors \u2013 HLA-C \u2013 implantation<\/jats:p>","DOI":"10.48095\/cccg2026226","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:05:00Z","timestamp":1785416700000},"page":"226-231","source":"Crossref","is-referenced-by-count":0,"title":["Current insights into the role of uterine natural killer cells in human reproduction"],"prefix":"10.48095","volume":"91","author":[{"given":"Pavel","family":"Otev\u0159el","sequence":"first","affiliation":[{"name":"Reprofit International s. r. o., Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"28151","published-online":{"date-parts":[[2026,6,26]]},"container-title":["\u010cesk\u00e1 gynekologie"],"original-title":["Current insights into the role of uterine natural killer cells in human reproduction"],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:05:02Z","timestamp":1785416702000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cs-gynekologie.cz\/en\/journals\/czech-gynaecology\/2026-3-7\/current-insights-into-the-role-of-uterine-natural-killer-cells-in-human-reproduction-144017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6,26]]},"published-print":{"date-parts":[[2026,6,26]]}},"URL":"https:\/\/doi.org\/10.48095\/cccg2026226","relation":{},"ISSN":["1210-7832","1805-4455"],"issn-type":[{"value":"1210-7832","type":"print"},{"value":"1805-4455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,26]]}}}