{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:13:13Z","timestamp":1788509593173,"version":"build-2803163510"},"reference-count":0,"publisher":"Care Comm","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ceska Gynekol"],"published-print":{"date-parts":[[2026,8,28]]},"abstract":"<jats:p>Objective: To assess dynamic thiol-disulfide homeostasis as a biomarker of oxidative stress in patients with endometrial cancer and to evaluate its association with tumor grade and stage. Methods: This prospective case-control study included 35 patients with histopathologically-confirmed endometrial cancer and 36 age-matched healthy controls. Venous blood samples were obtained after overnight fasting. Serum thiol-disulfide homeostasis parameters were measured using a fully-automated spectrophotometric method. Native thiol, total thiol, disulfide concentrations, and related ratios were analyzed. Tumor grade and International Federation of Gynecology and Obstetrics stage were recorded for all patients. Results: Native thiol and total thiol levels were significantly lower in patients with endometrial cancer compared with healthy controls (both P &lt; 0.001). Patients with grade 2 tumors exhibited significantly reduced native and total thiol levels compared with grade 1 patients and controls (P &lt; 0.001). A significant inverse correlation was observed between tumor stage and thiol levels, with lower native and total thiol concentrations in stage IB compared with stage IA disease (R = \u22120.586, and R = \u22120.604, resp.; P &lt; 0.001). Disulfide levels and thiol-disulfide ratios did not differ significantly between groups. Conclusion: Dynamic thiol-disulfide homeostasis is markedly impaired in endometrial cancer and is associated with tumor grade and stage. Reduced thiol levels reflect increased oxidative stress and diminished antioxidant capacity, suggesting that thiol-based redox parameters may serve as complementary biomarkers for disease severity and progression in endometrial cancer. \nKey words: endometrial cancer \u2013 oxidative stress \u2013 thiol-disulfide homeostasis \u2013 redox balance<\/jats:p>","DOI":"10.48095\/cccg2026306","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:26:40Z","timestamp":1788506800000},"page":"306-313","source":"Crossref","is-referenced-by-count":0,"title":["Oxidative stress and antioxidant imbalance in endometrial carcinogenesis"],"prefix":"10.48095","volume":"91","author":[{"given":"Jule Eri\u00e7","family":"Horasanl\u0131","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin","family":"Bah\u00e7eci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze","family":"Avc\u0131o\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif Caner","family":"Erdo\u011fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zcan","family":"Erel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Ne\u015felio\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"28151","published-online":{"date-parts":[[2026,8,30]]},"container-title":["\u010cesk\u00e1 gynekologie"],"original-title":["Oxidative stress and antioxidant imbalance in endometrial carcinogenesis"],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:26:42Z","timestamp":1788506802000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cs-gynekologie.cz\/en\/journals\/czech-gynaecology\/2026-4-5\/oxidative-stress-and-antioxidant-imbalance-in-endometrial-carcinogenesis-144300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8,30]]},"published-print":{"date-parts":[[2026,8,28]]}},"URL":"https:\/\/doi.org\/10.48095\/cccg2026306","relation":{},"ISSN":["1210-7832","1805-4455"],"issn-type":[{"value":"1210-7832","type":"print"},{"value":"1805-4455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]}}}