{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T18:53:25Z","timestamp":1766516005807,"version":"3.40.5"},"reference-count":0,"publisher":"Uppsala Medical Society","issue":"1","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ujms"],"abstract":"<jats:p>Background: Thymidine kinase 1 (TK1) is an intracellular protein associated with DNA synthesis, expressed during the G1 phase and remained elevated through the M phase, with a potential as a biomarker for cell proliferation. In this study, we explore the possible use of TK1 in Hodgkin lymphoma (HL).\r\nMethods: Serum concentrations of TK1 (S-TK1) were measured in 46 newly diagnosed HL patients using prospectively collected biobanked serum samples. The samples were analyzed using a novel antibody-based TK1 immunosorbent assay (ELISA).\r\nResults: The concentrations of S-TK1 were elevated in HL patients compared with healthy controls (median 0.32 \u03bcg\/L vs. 0.24 \u03bcg\/L,\u00a0P\u00a0= 0.003). A further increase in S-TK1 was observed during the treatment. The S-TK1 concentrations were higher in patients with advanced stage disease, low B-Hb, elevated P-LD and in those with B-symptoms. A high ESR correlated with low S-TK1.\r\nConclusions: The study results suggest that S-TK1, measured using a novel antibody-based assay, has the potential to be a biomarker in HL. However, while S-TK1 levels are elevated at baseline compared with healthy controls, a limited number of patients and comparatively short follow-up time render reliable conclusions difficult.<\/jats:p>","DOI":"10.48101\/ujms.v126.6119","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T10:56:21Z","timestamp":1629456981000},"source":"Crossref","is-referenced-by-count":2,"title":["Serum concentrations of Thymidine kinase 1 measured using a novel antibody-based assay in patients with Hodgkin Lymphoma"],"prefix":"10.48101","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0682-7394","authenticated-orcid":false,"given":"Johan","family":"Mattsson Ulfstedt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5863-790X","authenticated-orcid":false,"given":"Per","family":"Venge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Holmgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0594-724X","authenticated-orcid":false,"given":"Gunilla","family":"Enblad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Staffan","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Molin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"28163","published-online":{"date-parts":[[2021,8,20]]},"container-title":["Upsala Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/6119\/13785","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/6119\/13787","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/6119\/13786","content-type":"application\/epub+zip","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/6119\/13788","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/6119\/13785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T10:56:21Z","timestamp":1629456981000},"score":1,"resource":{"primary":{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/view\/6119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,20]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,25]]}},"URL":"https:\/\/doi.org\/10.48101\/ujms.v126.6119","relation":{},"ISSN":["2000-1967","0300-9734"],"issn-type":[{"type":"electronic","value":"2000-1967"},{"type":"print","value":"0300-9734"}],"subject":[],"published":{"date-parts":[[2021,8,20]]}}}