{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:12:04Z","timestamp":1788394324091,"version":"build-2803163510"},"reference-count":0,"publisher":"Uppsala Medical Society","license":[{"start":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T00:00:00Z","timestamp":1638489600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ujms"],"abstract":"<jats:p>Background: This study investigates the predictive value of the systemic immune-inflammation index (SII), which was calculated as platelet \u00d7 neutrophil\/lymphocyte ratio, for all-cause mortality in patients with hypertrophic cardiomyopathy (HCM).\r\nMethods: A total of 360 HCM patients were enrolled. They were divided into three groups based on the tertiles of baseline SII. The association between SII and all-cause mortality was analyzed.\r\nResults: There were 53 HCM patients who died during a mean follow-up time of 4.8 years (min: 6 days and max: 10.8 years), and the mortality rate was 3.0 per 100 person years. The cumulative mortality rate was significantly different among the three tertiles of SII (P\u202f=\u202f0.004), and the mortality rate in tertile 3 was much higher than that in the first two tertiles. In reference to tertile 1, the fully adjusted hazard ratios of all-cause mortality were 1.02 for the tertile 2 (95% confidence interval [CI]: 0.45\u20132.31,\u00a0P\u202f=\u202f0.966) and 2.31 for tertile 3 (95% CI: 1.10\u20134.87,\u00a0P\u202f=\u202f0.027). No significant interactions between SII and other variables were observed during subgroup analysis. The discriminative power was better for mid-term outcome than that for short-term or long-term outcomes. Sensitivity analyses including patients with normal platelet and white blood cell count have revealed similar results.\r\nConclusion: SII was a significant risk factor for all-cause mortality in HCM patients. However, the discriminative power was poor to moderate. It could be used in combination with other risk factors in mortality risk stratification in HCM.<\/jats:p>","DOI":"10.48101\/ujms.v126.8124","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T10:37:56Z","timestamp":1638527876000},"source":"Crossref","is-referenced-by-count":13,"title":["Assessing the relationship between systemic immune-inflammation index and mortality in patients with hypertrophic cardiomyopathy"],"prefix":"10.48101","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9777-2650","authenticated-orcid":false,"given":"Ziqiong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0446-2865","authenticated-orcid":false,"given":"Sen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"28163","published-online":{"date-parts":[[2021,12,3]]},"container-title":["Upsala Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/8124\/14121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/8124\/14124","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/8124\/14122","content-type":"application\/epub+zip","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/8124\/14123","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/8124\/14121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T10:37:57Z","timestamp":1638527877000},"score":1,"resource":{"primary":{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/view\/8124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.48101\/ujms.v126.8124","relation":{},"ISSN":["2000-1967","0300-9734"],"issn-type":[{"value":"2000-1967","type":"electronic"},{"value":"0300-9734","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12,3]]}}}