{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:03:40Z","timestamp":1787169820031,"version":"build-2736575974"},"reference-count":0,"publisher":"Uppsala Medical Society","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ujms"],"abstract":"<jats:p>Background and aim: As the spleen plays a significant role in immunity, the aim was to investigate the associations of different body composition markers derived from various sources with spleen volume in a general population sample.\r\nMaterials and methods: Cross-sectional data of 1095 individuals (570 women; 52%) aged between 30 and 90 years were collected in the Study of Health in Pomerania (SHIP-START-2). We measured spleen volume by magnetic resonance imaging (MRI).\r\nBody composition markers were derived from classic anthropometry, bioelectrical impedance analysis, including absolute fat mass (FM) and fat-free mass (FFM), as well as from MRI, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and liver fat content. Sex-stratified-adjusted linear regression models were used to analyze the associations of body composition markers with spleen volumes.\r\nResults: We observed positive associations of body mass index, body weight, waist circumference, hip circumference, waist-to-height ratio, absolute FM, absolute FFM, and VAT and SAT with spleen volume in men and women. An 8.12 kg higher absolute FFM was associated with a 38.4 mL (95% confidence interval [CI]: 26.7\u201350.1) higher spleen volume in men and a 5.21 kg higher absolute FFM with a 42.6 mL (95% CI: 26.2\u201359.0) higher spleen volume in women.\r\nConclusion: Our findings indicate that obesity-related body composition markers and FFM are associated with a higher spleen volume. Particularly, higher absolute FFM showed a strong association with a larger spleen volume in both men and women. Further studies are warranted to understand the clinical significance of body composition markers on large spleen volume.<\/jats:p>","DOI":"10.48101\/ujms.v129.10465","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T05:55:11Z","timestamp":1717048511000},"page":"e10465","source":"Crossref","is-referenced-by-count":7,"title":["Central obesity and fat-free mass are associated with a larger spleen volume in the general population"],"prefix":"10.48101","volume":"129","author":[{"given":"Mohammed Farah Mahmoud","family":"Mousa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naeem","family":"Muhammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Bibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"B\u00fclow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bahls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Siewert-Markus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"T\u00f6pfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Aghdassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Nasir","family":"Khan Khattak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"V\u00f6lzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello RP","family":"Markus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Ittermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"28163","published-online":{"date-parts":[[2024,5,30]]},"container-title":["Upsala Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/10465\/17317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/10465\/17311","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/10465\/17312","content-type":"application\/epub+zip","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/10465\/17315","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/10465\/17317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T05:55:11Z","timestamp":1717048511000},"score":1,"resource":{"primary":{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/view\/10465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.48101\/ujms.v129.10465","relation":{},"ISSN":["2000-1967","0300-9734"],"issn-type":[{"value":"2000-1967","type":"electronic"},{"value":"0300-9734","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,30]]}}}