{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:55:10Z","timestamp":1790870110493,"version":"4.1.0"},"reference-count":0,"publisher":"Uppsala Medical Society","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ujms"],"abstract":"<jats:p>Introduction: Post-transplant erythrocytosis following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rare and has been reported mainly in patients with aplastic anemia and, less frequently, after transplantation for other hematologic conditions. Here, we present two cases of JAK2V617F-positive polycythemia vera (PV) developing after allo-HSCT performed for chronic myeloid leukemia (CML) and myelodysplastic syndrome (MDS).\r\nCase presentations: Case 1: The patient, who underwent allo-HSCT for the diagnosis of MDS. He was diagnosed with JAK2V617F-positive PV, 48 months after transplantation. Case 2: The patient with chronic-phase CML underwent allo-HSCT while in hematologic remission. Approximately 10 years later, the patient was diagnosed with JAK2V617F-positive PV.\r\nDiscussion: Possible explanations for the development of a JAK2V617F mutation after allo-HSCT include the expansion of a pre-existing but clinically silent mutant clone in the donor, or the emergence of de novo mutations in donor or recipient cells as a result of proliferative stress, immunosuppression, or prior chemotherapy.<\/jats:p>","DOI":"10.48101\/ujms.v131.14276","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:00:27Z","timestamp":1790866827000},"page":"e14276","source":"Crossref","is-referenced-by-count":0,"title":["De novo development of JAK2V617F-positive polycythemia vera following allogeneic hematopoietic stem cell transplantation: a report of two rare cases"],"prefix":"10.48101","volume":"131","author":[{"given":"Gulten","family":"Korkmaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"28163","published-online":{"date-parts":[[2026,10,1]]},"container-title":["Upsala Journal of Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/14276\/21937","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/14276\/21934","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/14276\/21935","content-type":"application\/epub+zip","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/14276\/21936","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/download\/14276\/21937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:00:27Z","timestamp":1790866827000},"score":1,"resource":{"primary":{"URL":"https:\/\/ujms.net\/index.php\/ujms\/article\/view\/14276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":0,"URL":"https:\/\/doi.org\/10.48101\/ujms.v131.14276","relation":{},"ISSN":["2000-1967","0300-9734"],"issn-type":[{"value":"2000-1967","type":"electronic"},{"value":"0300-9734","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10,1]]}}}