{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:56:18Z","timestamp":1777892178985,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the Royal College of Physicians of Edinburgh"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>Etoposide, methylprednisolone, cytarabine and cisplatin (ESHAP) is one of the mostly widely used chemotherapy regimens for patients with relapsed lymphomas. Cisplatin administration is commonly associated with electrolyte imbalance. Careful monitoring of renal function and serum electrolytes is therefore essential in this setting.<\/jats:p>\n                  <jats:p>Aims: To review the practice of electrolyte monitoring \u2013 potassium (K), calcium (Ca) and magnesium (Mg) \u2013 in patients receiving ESHAP and the frequency and severity of abnormalities and their management.<\/jats:p>\n                  <jats:p>Methods: Twenty-one consecutive patients received ESHAP. The medical records of 16 patients were retrievable and reviewed retrospectively. Results of serum K, Ca and Mg were collected prior to and after cycles 1, 2 and 3 of ESHAP, if measured.<\/jats:p>\n                  <jats:p>Results: Serum K levels prior to every cycle did not show any noticeable change. The means were 4.42, 4.34 and 4.43 mmol\/l before cycles 1, 2 and 3, respectively. In one patient hypokalaemia was severe, refractory and symptomatic when preceded by hypomagnesaemia. Serum-adjusted calcium levels showed only minimal reduction. The means were 2.46, 2.40 and 2.38 mmol\/l before cycles 1, 2 and 3 respectively. Mean serum Mg levels prior to every cycle showed progressive reduction; 0.84, 0.75 and 0.67 mmol\/l before cycles 1, 2 and 3, respectively. This was associated with a progressive increase in the amount of required Mg supplementation. Serum K, Ca and Mg was measured prior to 100%, 67% and 35% of administered cycles, respectively.<\/jats:p>\n                  <jats:p>Conclusion: In patients receiving ESHAP, hypokalaemia can occasionally be seen, especially if preceded by hypomagnesaemia. Mild cumulative hypocalcaemia is recognised. Hypomagnesaemia is a progressive complication and physicians need be aware of its importance.<\/jats:p>","DOI":"10.4997\/jrcpe.2009.403","type":"journal-article","created":{"date-parts":[[2009,12,10]],"date-time":"2009-12-10T10:38:34Z","timestamp":1260441514000},"page":"301-306","source":"Crossref","is-referenced-by-count":5,"title":["Serum potassium, calcium and magnesium in patients receiving ESHAP chemotherapy for relapsed lymphomas"],"prefix":"10.1177","volume":"39","author":[{"given":"J","family":"Zekri","sequence":"first","affiliation":[{"name":"Specialist Registrar in Medical Oncology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NLC","family":"Cheah","sequence":"additional","affiliation":[{"name":"Senior House Officer in Oncology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Evans","sequence":"additional","affiliation":[{"name":"Consultant Medical Oncologist"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Hancock","sequence":"additional","affiliation":[{"name":"Professor of Medical Oncology, Academic Unit of Clinical Oncology, Cancer Research Centre, Weston Park Hospital, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,12,1]]},"reference":[{"key":"bibr1-JRCPE.2009.403","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2002.17.5.621"},{"key":"bibr2-JRCPE.2009.403","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.6.1169"},{"key":"bibr3-JRCPE.2009.403","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-004-0899-6"},{"key":"bibr4-JRCPE.2009.403","first-page":"105","volume":"23","author":"Elisaf M","year":"1997","journal-title":"Miner Electrolyte Metab"},{"key":"bibr5-JRCPE.2009.403","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-6-128"},{"key":"bibr6-JRCPE.2009.403","first-page":"75","volume":"9","author":"Schilsky RL.","year":"1982","journal-title":"Semin Oncol"},{"key":"bibr7-JRCPE.2009.403","doi-asserted-by":"crossref","unstructured":"7 Cvitkovic E, Spaulding J, Bethune V  Improvement of cisdichlorodiammineplatinum (NSC 119875): therapeutic index in an animal model. Cancer 1977; 39:1357\u201361. doi:10.1002\/1097-0142(197704)39:4<1357:AID-CNCR2820390402>3.0.CO;2-C","DOI":"10.1002\/1097-0142(197704)39:4<1357::AID-CNCR2820390402>3.0.CO;2-C"},{"key":"bibr8-JRCPE.2009.403","doi-asserted-by":"crossref","unstructured":"8 Hayes D, Cvitkovic E, Golbey R  High dose cis-platinum diamine dichloride: amelioration of renal toxicity by mannitol diuresis. Cancer 1977; 39:1372. doi:10.1002\/1097-0142(197704)39:4<1372:AIDCNCR2820390404>3.0.CO;2-J","DOI":"10.1002\/1097-0142(197704)39:4<1372::AID-CNCR2820390404>3.0.CO;2-J"},{"key":"bibr9-JRCPE.2009.403","doi-asserted-by":"publisher","DOI":"10.1177\/106002809302701219"},{"key":"bibr10-JRCPE.2009.403","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1994.1010"},{"key":"bibr11-JRCPE.2009.403","doi-asserted-by":"crossref","unstructured":"11 Dentino M, Luft FC, Yum MN  Long term effect of cisdiamminedichloride platinum (CDDP) on renal function and structure in man. Cancer 1978; 41:1274\u201381. doi:10.1002\/1097-0142(197804)41:4<1274:AID-CNCR2820410410>3.0.CO;2-F","DOI":"10.1002\/1097-0142(197804)41:4<1274::AID-CNCR2820410410>3.0.CO;2-F"},{"key":"bibr12-JRCPE.2009.403","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1985.3.9.1251"},{"key":"bibr13-JRCPE.2009.403","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1989.00390110136030"},{"key":"bibr14-JRCPE.2009.403","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1992.00400130066006"},{"key":"bibr15-JRCPE.2009.403","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(04)80177-2"},{"key":"bibr16-JRCPE.2009.403","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(85)80255-6"},{"key":"bibr17-JRCPE.2009.403","first-page":"151","volume":"7","year":"1986","journal-title":"Int J Pediatr Nephrol"},{"key":"bibr18-JRCPE.2009.403","doi-asserted-by":"crossref","unstructured":"18 Ariceta G, Rodriguez-Soriano J, Vallo A  Acute and chronic effects of cisplatin therapy on renal magnesium homeostasis. Med Pediatr Oncol 1997; 28:35\u201340. doi:10.1002\/(SICI)1096-911X(199701)28:1<35:AIDMPO7>3.0.CO;2-U","DOI":"10.1002\/(SICI)1096-911X(199701)28:1<35::AID-MPO7>3.0.CO;2-U"},{"key":"bibr19-JRCPE.2009.403","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(83)90156-7"},{"key":"bibr20-JRCPE.2009.403","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20804"},{"key":"bibr21-JRCPE.2009.403","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2008.01.007"},{"key":"bibr22-JRCPE.2009.403","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90900-4"},{"key":"bibr23-JRCPE.2009.403","first-page":"132","volume":"9","author":"Rolla G","year":"1990","journal-title":"Magnes Trace Elem"},{"key":"bibr24-JRCPE.2009.403","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006490226104"}],"container-title":["Journal of the Royal College of Physicians of Edinburgh"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/JRCPE.2009.403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/JRCPE.2009.403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:22:29Z","timestamp":1777616549000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4997\/JRCPE.2009.403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.4997\/JRCPE.2009.403"],"URL":"https:\/\/doi.org\/10.4997\/jrcpe.2009.403","relation":{},"ISSN":["1478-2715","2042-8189"],"issn-type":[{"value":"1478-2715","type":"print"},{"value":"2042-8189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}