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We report on a young patient who initially presented with diabetes insipidus and subsequently with pyrexia of unknown origin. She progressed from single system Langerhans cell histiocytosis to multisystem involvement and remains in long-term remission following chemotherapy.<\/jats:p>","DOI":"10.4997\/jrcpe.2012.406","type":"journal-article","created":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T05:24:23Z","timestamp":1355462663000},"page":"311-313","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Langerhans cell histiocytosis: a multisystem disorder"],"prefix":"10.1177","volume":"42","author":[{"given":"A","family":"Munir","sequence":"first","affiliation":[{"name":"Specialty Registrar Diabetes and Endocrinology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Leech","sequence":"additional","affiliation":[{"name":"Consultant Diabetologist"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KP","family":"Windebank","sequence":"additional","affiliation":[{"name":"Consultant Paediatric and Adolescent Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"McLelland","sequence":"additional","affiliation":[{"name":"Consultant Dermatologist"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GL","family":"Jones","sequence":"additional","affiliation":[{"name":"Consultant Haematologist"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Mitra","sequence":"additional","affiliation":[{"name":"Consultant Radiologist"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Consultant Neurosurgeon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Quinton","sequence":"additional","affiliation":[{"name":"Consultant Endocrinologist, Royal Victoria Infirmary, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,12,1]]},"reference":[{"key":"bibr1-JRCPE.2012.406","first-page":"S37","volume":"23","author":"Kannourakis G","year":"1994","journal-title":"Br J Cancer Suppl"},{"key":"bibr2-JRCPE.2012.406","first-page":"4195","volume":"94","author":"Egeler RM","year":"1999","journal-title":"Blood"},{"key":"bibr3-JRCPE.2012.406","first-page":"1301","volume":"136","author":"Ornvold K","year":"1990","journal-title":"Am J Pathol"},{"key":"bibr4-JRCPE.2012.406","doi-asserted-by":"crossref","unstructured":"4 Halton J, Whitton A, Wiernikowski J  Disseminated Langerhans cell histiocytosis in identical twins unresponsive to recombinant human alpha-interferon and total body irradiation. 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J Clin Endocrinol Metab 2000; 85:1370\u20136. http:\/\/dx.doi.org\/10.1210\/jc.85.4.1370","DOI":"10.1210\/jc.85.4.1370"},{"key":"bibr10-JRCPE.2012.406","first-page":"370","volume":"12","author":"Kaplan KJ","year":"1999","journal-title":"Mod Pathol"},{"key":"bibr11-JRCPE.2012.406","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-002-0565-x"},{"key":"bibr12-JRCPE.2012.406","first-page":"615","volume":"32","author":"Lau SK","year":"2008","journal-title":"Immunohistochemical expression of langerin in Langerhans cell histiocytosis and non-Langerhans cell histiocytic disorders"},{"key":"bibr13-JRCPE.2012.406","doi-asserted-by":"crossref","unstructured":"13 Broadbent V, Gadner H. Current therapy for Langerhans cell histiocytosis. Hematol Oncol Clin North Am 1998; 12:327\u201338. http:\/\/dx.doi.org\/10.1016\/S0889-8588(05)70513-X","DOI":"10.1016\/S0889-8588(05)70513-X"},{"key":"bibr14-JRCPE.2012.406","doi-asserted-by":"crossref","unstructured":"14 Gadner H, Heitger A, Grois N  Treatment strategy for disseminated Langerhans cell histiocytosis. DAL HX-83 Study Group. Med Pediatr Oncol 1994; 23:72\u201380. http:\/\/dx.doi.org\/10.1002\/mpo.2950230203","DOI":"10.1002\/mpo.2950230203"},{"key":"bibr15-JRCPE.2012.406","doi-asserted-by":"crossref","unstructured":"15 Gadner H, Grois N, Potschger U  Improved outcome in multisystem Langerhans cell histiocytosis is associated with therapy intensification. 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