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Whether Abraham Lincoln suffered from Marfan syndrome, if George III became \u2018mad\u2019 because he inherited variegate porphyria, and if the Romanov dynasty collapsed because the heir Alexei inherited haemophilia are important questions; physical illness can adversely affect the ability of leaders to function within the social and political realm of their day. This article will outline an approach to such a medicalhistorical analysis including assessment of hereditary predisposition, family history and the use of DNA technology to confirm or deny the clinical suspicions of the investigator.<\/jats:p>","DOI":"10.4997\/jrcpe.2013.103","type":"journal-article","created":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T04:35:30Z","timestamp":1363926930000},"page":"11-14","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnosing the dead: the retrospective analysis of genetic diseases"],"prefix":"10.1177","volume":"43","author":[{"given":"AR","family":"Rushton","sequence":"first","affiliation":[{"name":"Paediatrician and Medical Geneticist, Department of Pediatrics, Hunterdon Medical Center, New Jersey, USA; *Fellow of the Royal Society of Medicine London and the Red-Headed League of New Jersey (Emeritus)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"key":"bibr1-JRCPE.2013.103","unstructured":"1 Porter R, editor. 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