{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:58:54Z","timestamp":1777892334938,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal College of Physicians of Edinburgh"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>Urticaria, also known as hives, and angioedema, where the swelling occurs below the skin instead of on the skin, are extremely common but there is a misconception that the most likely cause is an allergic reaction. Chronic urticaria in particular is rarely due to allergy. Equally for angioedema, many will consider the exceptionally rare hereditary angioedema (HAE), but in fact other medical causes are the most likely, in particular the use of angiotensin-converting enzyme inhibitor (ACE-I) drugs. Approximately 3\u20135% of patients receiving ACE-I will develop angioedema at some time in the course of their treatment.1 Stress is a major contributor to both chronic urticaria and recurrent angioedema. Treatment needs to focus on the use of long-acting, non-sedating, antihistamines. Corticosteroids may be used acutely but not long term.<\/jats:p>","DOI":"10.4997\/jrcpe.2014.112","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T08:11:28Z","timestamp":1395130288000},"page":"50-54","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Urticaria and angioedema"],"prefix":"10.1177","volume":"44","author":[{"given":"G","family":"Spickett","sequence":"first","affiliation":[{"name":"Consultant Clinical Immunologist, Regional Department of Immunology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,3,1]]},"reference":[{"key":"bibr1-JRCPE.2014.112","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.111387"},{"key":"bibr2-JRCPE.2014.112","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-05659-5.00061-9"},{"key":"bibr3-JRCPE.2014.112","doi-asserted-by":"crossref","unstructured":"3Personal observations and Ben-Shoshan M, Blinderman I, Raz A. Psychosocial factors and chronic spontaneous urticaria: a systematic review. Allergy 2013; 68:131\u201341. http:\/\/dx.doi.org\/10.1111\/all.12068","DOI":"10.1111\/all.12068"},{"key":"bibr4-JRCPE.2014.112","first-page":"6","volume":"43","year":"2012","journal-title":"BPJ"},{"key":"bibr5-JRCPE.2014.112","doi-asserted-by":"crossref","unstructured":"2 Grattan CEH, Humphreys F, on behalf of the British Association of Dermatologists Therapy Guidelines and Audit Subcommittee. Guidelines for evaluation and management of urticaria in adults and children. Br J Dermatol 2007; 157:1116\u201323. http:\/\/dx.doi.org\/10.1111\/j.1365-2133.2007.08283.x","DOI":"10.1111\/j.1365-2133.2007.08283.x"},{"key":"bibr6-JRCPE.2014.112","first-page":"326","volume":"4","author":"Kaplan AP.","year":"2012","journal-title":"Treatment of chronic spontaneous urticaria"},{"key":"bibr7-JRCPE.2014.112","doi-asserted-by":"crossref","unstructured":"4 Powell RJ, GL Du Toit, Siddique WN  BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy 2007; 37:631\u201350. http:\/\/dx.doi.org\/10.1111\/j.1365-2222.2007.02678.x","DOI":"10.1111\/j.1365-2222.2007.02678.x"},{"key":"bibr8-JRCPE.2014.112","doi-asserted-by":"crossref","unstructured":"5 Zuberbier T, Asero R, Bindslev-Jensen C  EAACI\/GA(2)LEN\/EDF\/WAO guideline: management of urticarial. Allergy 2009; 64:1427\u201343. http:\/\/dx.doi.org\/10.1111\/j.1398-9995.2009.02178.x","DOI":"10.1111\/j.1398-9995.2009.02178.x"}],"container-title":["Journal of the Royal College of Physicians of Edinburgh"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/JRCPE.2014.112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/JRCPE.2014.112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:27:01Z","timestamp":1777616821000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4997\/JRCPE.2014.112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.4997\/JRCPE.2014.112"],"URL":"https:\/\/doi.org\/10.4997\/jrcpe.2014.112","relation":{},"ISSN":["1478-2715","2042-8189"],"issn-type":[{"value":"1478-2715","type":"print"},{"value":"2042-8189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}