{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T02:46:36Z","timestamp":1780454796417,"version":"3.54.1"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal College of Physicians of Edinburgh"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Isolated mediastinal lymphadenopathy is an increasingly common finding as a result of the increasing use of cross-sectional thoracic imaging. We investigated the performance of endobronchial ultrasound-guided transbronchial needle-aspiration (EBUS-TBNA) in establishing a pathological diagnosis in patients with isolated mediastinal lymphadenopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed all consecutive EBUS-TBNA examinations performed over a 4-year period at a single tertiary referral centre. Final diagnoses were made using pathology reports, correlated with clinical features and the results of any other investigations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 126 EBUS-TBNA examinations were performed to investigate isolated mediastinal lymphadenopathy. A positive pathological diagnosis was made following EBUS-TBNA in 54 cases (43%). When the results of further investigations and variable radiological follow up were included, the final sensitivity of EBUS-TBNA for making a diagnosis in isolated mediastinal lymphadenopathy was 80% (95% CI 69%-89%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study confirms that EBUS-TBNA has acceptable sensitivity for detecting both benign and malignant pathologies underlying isolated mediastinal lymphadenopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4997\/jrcpe.2017.111","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T10:44:14Z","timestamp":1498646654000},"page":"52-56","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Isolated Mediastinal Lymphadenopathy -Performance of Ebus-Tbna in Clinical Practice"],"prefix":"10.1177","volume":"47","author":[{"given":"PP","family":"Velu","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PA","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Western General Hospital, Edinburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WA","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KM","family":"Skwarski","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"bibr1-jrcpe.2017.111","volume":"31","author":"Evison M","year":"2014","journal-title":"BMJ Open Respir Res"},{"key":"bibr2-jrcpe.2017.111","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(97)00324-2"},{"key":"bibr3-jrcpe.2017.111","doi-asserted-by":"publisher","DOI":"10.4997\/JRCPE.2013.211"},{"key":"bibr4-jrcpe.2017.111","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.39"},{"key":"bibr5-jrcpe.2017.111","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00029-6"},{"key":"bibr6-jrcpe.2017.111","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201203-0393OC"},{"key":"bibr7-jrcpe.2017.111","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0998"},{"key":"bibr8-jrcpe.2017.111","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2768"},{"key":"bibr9-jrcpe.2017.111","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.08.051"},{"key":"bibr10-jrcpe.2017.111","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.038901"}],"container-title":["Journal of the Royal College of Physicians of Edinburgh"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/jrcpe.2017.111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/jrcpe.2017.111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:29:16Z","timestamp":1777616956000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4997\/jrcpe.2017.111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.4997\/jrcpe.2017.111"],"URL":"https:\/\/doi.org\/10.4997\/jrcpe.2017.111","relation":{},"ISSN":["1478-2715","2042-8189"],"issn-type":[{"value":"1478-2715","type":"print"},{"value":"2042-8189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}