{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:59:21Z","timestamp":1777892361687,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal College of Physicians of Edinburgh"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>The incidence of syphilis in the UK is rapidly rising. Uveitis (intraocular inflammation) usually occurs in the secondary or later stages of syphilis infection and is sight-threatening.<\/jats:p>\n                  <jats:p>Methods A retrospective analysis of the demographics, presentation, diagnosis, treatment and outcomes of patients with syphilitic uveitis managed in Newcastle from 2005\u20132016 was carried out.<\/jats:p>\n                  <jats:p>Results Ten males (19 eyes) with syphilitic uveitis had a generally good visual and serological response to penicillin treatment. In eight of the patients there had been a failure to test for syphilis during assessments by various medical practitioners for unexplained symptoms that were attributable to syphilis prior to the eye involvement.<\/jats:p>\n                  <jats:p>Conclusion Uveitis associated with syphilis can be sight-threatening but responds well to treatment. In our case series there were multiple missed opportunities to diagnose syphilis prior to presentation with eye disease, with a general failure of healthcare professionals to take an adequate sexual history.<\/jats:p>","DOI":"10.4997\/jrcpe.2017.204","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T10:08:59Z","timestamp":1499162939000},"page":"129-134","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Missed opportunities to diagnose syphilis prior to the development of sight-losing uveitis"],"prefix":"10.1177","volume":"47","author":[{"given":"JD","family":"Widdrington","sequence":"first","affiliation":[{"name":"Specialty Trainees, Department of Infection and Tropical Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Ashfaq","sequence":"additional","affiliation":[{"name":"Retinal Fellow, Department of Ophthalmology;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Puvaneswaran","sequence":"additional","affiliation":[{"name":"Specialty Trainees, Department of Infection and Tropical Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EL","family":"Ong","sequence":"additional","affiliation":[{"name":"Consultants, Department of Infection and Tropical Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Schwab","sequence":"additional","affiliation":[{"name":"Consultants, Department of Infection and Tropical Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DA","family":"Price","sequence":"additional","affiliation":[{"name":"Consultants, Department of Infection and Tropical Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ML","family":"schmid","sequence":"additional","affiliation":[{"name":"Consultant, Department of Ophthalmology, Newcastle upon Tyne Hospitals NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Pandit","sequence":"additional","affiliation":[{"name":"Consultant, Department of Ophthalmology, Newcastle upon Tyne Hospitals NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"bibr1-JRCPE.2017.204","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-016-0542-9"},{"key":"bibr2-JRCPE.2017.204","unstructured":"2 Harman LE, CE Margo, Roetzheim RG. Uveitis: the collaborative diagnostic evaluation. Am Fam Physician 2014; 90: 711-6."},{"key":"bibr3-JRCPE.2017.204","doi-asserted-by":"crossref","volume-title":"Management of adult syphilis","author":"Ghanem KG","DOI":"10.1093\/cid\/cir701"},{"key":"bibr4-JRCPE.2017.204","doi-asserted-by":"crossref","unstructured":"4 Janier M, V Hegyi, Dupin N  2014 European guideline on the management of syphilis. J Eur Acad Dermatol Venereol 2014; 28: 1581-93.","DOI":"10.1111\/jdv.12734"},{"key":"bibr5-JRCPE.2017.204","doi-asserted-by":"crossref","unstructured":"5 Kingston M, French P Higgins S  UK national guidelines on the management of syphilis 2015. Int J STD AIDS 2016; 27: 421-46.","DOI":"10.1177\/0956462415624059"},{"key":"bibr6-JRCPE.2017.204","doi-asserted-by":"crossref","unstructured":"6 Oliver SE, M Aubin, Atwell L  Ocular Syphilis - Eight Jurisdictions, United States, 2014-2015. MMWR Morb Mortal Wkly Rep 2016; 65: 1185-8.","DOI":"10.15585\/mmwr.mm6543a2"},{"key":"bibr7-JRCPE.2017.204","unstructured":"7Public Health England. Health Protection Report: Infection Report.2016. https:\/\/www.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/559993\/hpr2216_stis_CRRCTD4.pdf (accessed 4\/5\/17)."},{"key":"bibr8-JRCPE.2017.204","unstructured":"8CDC. Clinical advisory: ocular syphilis in the United States.2016. http:\/\/www.cdc.gov\/std\/syphilis\/clinicaladvisoryos2015.htm (accessed 4\/5\/17)."},{"key":"bibr9-JRCPE.2017.204","first-page":"1288","volume":"97","author":"Gass JD","journal-title":"Acute syphilitic posterior placoid chorioretinitis"},{"key":"bibr10-JRCPE.2017.204","first-page":"509","volume":"140","author":"Jabs DA","journal-title":"Standardization of uveitis nomenclature for reporting clinical data"},{"key":"bibr11-JRCPE.2017.204","doi-asserted-by":"crossref","unstructured":"11 Mathew RG, BT Goh, Westcott MC. British Ocular Syphilis Study (BOSS): 2-year national surveillance study of intraocular inflammation secondary to ocular syphilis. Invest Ophthalmol Vis Sci 2014; 55: 5394-400.","DOI":"10.1167\/iovs.14-14559"},{"key":"bibr12-JRCPE.2017.204","doi-asserted-by":"crossref","unstructured":"12 Eandi CM, Neri P Adelman RA  Acute syphilitic posterior placoid chorioretinitis: report of a case series and comprehensive review of the literature. Retina 2012; 32: 1915-41.","DOI":"10.1097\/IAE.0b013e31825f3851"},{"key":"bibr13-JRCPE.2017.204","doi-asserted-by":"publisher","DOI":"10.1186\/s12348-015-0056-x"},{"key":"bibr14-JRCPE.2017.204","doi-asserted-by":"crossref","unstructured":"14 Northey LC, SE Skalicky, Gurbaxani A  Syphilitic uveitis and optic neuritis in Sydney, Australia. Br J Ophthalmol 2015; 99: 1215-9.","DOI":"10.1136\/bjophthalmol-2014-306168"},{"key":"bibr15-JRCPE.2017.204","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2797028"},{"key":"bibr16-JRCPE.2017.204","unstructured":"16 Brook G, L Bacon, C Evans, McClean H  2013 UK national guideline for consultations requiring sexual history taking. 2013; https:\/\/www.bashh.org\/documents\/SexualHistoryGuidelines2013final.pdf (accessed 4\/5\/17)."},{"key":"bibr17-JRCPE.2017.204","doi-asserted-by":"crossref","unstructured":"17 Tsimtsiou Z, K Hatzimouratidis, Nakopoulou E  Predictors of physicians involvement in addressing sexual health issues. 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