{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:38:12Z","timestamp":1787031492551,"version":"build-2736575974"},"reference-count":6,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal College of Physicians of Edinburgh"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adenosine is frequently used during coronary angiography to induce hyperaemia and allow operators to perform quantitative measurements of lesion severity. Acute bronchospasm is a recognised side effect relating to the activation of \u2018off target\u2019 A2B receptors. The true incidence of severe bronchospasm relating to adenosine administration is not known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using an electronic patient database, we analysed 100,253 consecutive coronary angiograms over almost 19 years. Fractional flow reserve (FFR) was measured under systemic adenosine in 9,440 cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Adenosine-related bronchospasm was reported in only five cases (0.05%). One case resulted in a life-threatening respiratory arrest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study reveals the incidence of acute bronchospasm during FFR testing to be extremely low. Although rare, these reactions can be severe and are not simply limited to patients with brittle airways disease. Physicians should be aware of the utility of bolus intravenous aminophylline providing targeted therapy to reverse and treat adenosine-related bronchospasm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4997\/jrcpe.2019.307","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T06:04:11Z","timestamp":1568009051000},"page":"204-206","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Incidence of Acute Bronchospasm during Systemic Adenosine Administration for Coronary Angiography"],"prefix":"10.1177","volume":"49","author":[{"given":"Andrew","family":"Morrow","sequence":"first","affiliation":[{"name":"Clinical Fellow in Interventional Caradiology, Golden Jubilee National Hospital, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J","family":"Ford","sequence":"additional","affiliation":[{"name":"British Heart Foundation Clinical Research Fellow, British Heart Foundation Glasgow Cardiovascular Research Centre (University of Glasgow), Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Brogan","sequence":"additional","affiliation":[{"name":"Consultant Interventional Cardiologist, Golden Jubilee National Hospital, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,1]]},"reference":[{"key":"bibr1-jrcpe.2019.307","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199606273342604"},{"key":"bibr2-jrcpe.2019.307","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15022024"},{"key":"bibr3-jrcpe.2019.307","doi-asserted-by":"publisher","DOI":"10.1513\/pats.P09ST1"},{"key":"bibr4-jrcpe.2019.307","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90424-3"},{"key":"bibr5-jrcpe.2019.307","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1700445"},{"key":"bibr6-jrcpe.2019.307","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-016-0452-0"}],"container-title":["Journal of the Royal College of Physicians of Edinburgh"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/jrcpe.2019.307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/jrcpe.2019.307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:31:48Z","timestamp":1777617108000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4997\/jrcpe.2019.307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.4997\/jrcpe.2019.307"],"URL":"https:\/\/doi.org\/10.4997\/jrcpe.2019.307","relation":{},"ISSN":["1478-2715","2042-8189"],"issn-type":[{"value":"1478-2715","type":"print"},{"value":"2042-8189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]}}}