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She was the first to clearly demonstrate that strength temporarily improved in patients with myasthenia gravis with physostigmine or Prostigmin (neostigmine). This dramatic treatment response has been erroneously termed the \u2018Mary Walker effect'. Further, she noted hypokalaemia during attacks of weakness in familial periodic paralysis, pioneering treatment with potassium chloride. Although Mary Walker practiced in a nonacademic setting and trained at a time when women were not allowed to train alongside men, she was the first to convincingly demonstrate three life-changing treatments in the field of neuromuscular medicine, a feat that few physicians of any era can claim.<\/jats:p>","DOI":"10.4997\/jrcpe.2019.317","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T06:04:11Z","timestamp":1568009051000},"page":"255-259","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Mary Walker Effect: Mary Broadfoot Walker"],"prefix":"10.1177","volume":"49","author":[{"given":"Stuart J","family":"McCarter","sequence":"first","affiliation":[{"name":"Neurology Resident, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B","family":"Burkholder","sequence":"additional","affiliation":[{"name":"Assistant Professor of Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P","family":"Klaas","sequence":"additional","affiliation":[{"name":"Assistant Professor of Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M","family":"Martinez-Thompson","sequence":"additional","affiliation":[{"name":"Assistant Professor of Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J","family":"Boes","sequence":"additional","affiliation":[{"name":"Professor of Neurology, Department of Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,1]]},"reference":[{"key":"bibr1-jrcpe.2019.317","first-page":"1401","volume":"2","author":"KSM","year":"1974","journal-title":"Lancet"},{"key":"bibr2-jrcpe.2019.317","doi-asserted-by":"publisher","DOI":"10.1007\/BF02569052"},{"key":"bibr3-jrcpe.2019.317","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.5.1433"},{"key":"bibr4-jrcpe.2019.317","unstructured":"Anonymous. 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