{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:02:40Z","timestamp":1777892560392,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal College of Physicians of Edinburgh"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although there are numerous studies on meningitis and encephalitis separately, literature on meningoencephalitis is sparse. In this study we analysed the clinical profile of meningoencephalitis and its clinical outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty adults diagnosed with meningoencephalitis from July 2014 to July 2015 in a tertiary care hospital in South India were studied prospectively and their clinical presentation, aetiology and outcome were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 50 patients, 33 (66%) were male; 39 (78%) were &lt;50 years of age. Fever was the most common presenting symptom in 41 out of 50 patients (82%), followed by headache (74%) and altered sensorium (62%); only 18 patients (36%) had all three classical symptoms. Twenty-eight out of 50 patients (56%) did not have neck stiffness. A majority of patients had acute-to-subacute clinical presentation. Mycobacterium tuberculosis was identified in 58% (29 out of 50). Forty-seven patients (94%) recovered completely.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tuberculosis was the most common cause of meningoencephalitis in the studied population, often with subacute presentation, and outcome was good with early institution of antituberculous therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4997\/jrcpe.2019.406","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T11:15:08Z","timestamp":1575544508000},"page":"282-286","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["A Prospective Study on the Clinical Profile and Outcome of Meningoencephalitis in Adults in a South Indian Tertiary Care Centre"],"prefix":"10.1177","volume":"49","author":[{"given":"Velammal","family":"Petchiappan","sequence":"first","affiliation":[{"name":"Associate Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Pedireddy","sequence":"additional","affiliation":[{"name":"Senior Resident, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santni","family":"Manickam","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayachandran","family":"Kuppusamy","sequence":"additional","affiliation":[{"name":"Professor of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,12,1]]},"reference":[{"key":"bibr1-jrcpe.2019.406","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.157396"},{"key":"bibr2-jrcpe.2019.406","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-11_Part_1-199812010-00004"},{"key":"bibr3-jrcpe.2019.406","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2008.02.002"},{"key":"bibr4-jrcpe.2019.406","doi-asserted-by":"publisher","DOI":"10.1016\/S0072-9752(09)96004-3"},{"key":"bibr5-jrcpe.2019.406","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-007-0049-5"},{"key":"bibr6-jrcpe.2019.406","first-page":"5","volume":"52","author":"Rich AR","year":"1933","journal-title":"Bull John Hopkins Hospital"},{"key":"bibr7-jrcpe.2019.406","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2007.10.001"},{"key":"bibr8-jrcpe.2019.406","volume":"2","author":"Khajeh A","year":"2015","journal-title":"Int J Infect"},{"key":"bibr9-jrcpe.2019.406","first-page":"61","volume":"14","author":"Mahoney FI","year":"1965","journal-title":"Md State Med J"},{"key":"bibr10-jrcpe.2019.406","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040845"},{"key":"bibr11-jrcpe.2019.406","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00430-2"},{"key":"bibr12-jrcpe.2019.406","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(95)80001-8"},{"key":"bibr13-jrcpe.2019.406","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(99)90095-6"},{"key":"bibr14-jrcpe.2019.406","doi-asserted-by":"publisher","DOI":"10.1086\/367841"},{"key":"bibr15-jrcpe.2019.406","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-55-651-189"},{"key":"bibr16-jrcpe.2019.406","doi-asserted-by":"publisher","DOI":"10.1258\/rsmacta.41.1.13"}],"container-title":["Journal of the Royal College of Physicians of Edinburgh"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/jrcpe.2019.406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/jrcpe.2019.406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:32:03Z","timestamp":1777617123000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4997\/jrcpe.2019.406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.4997\/jrcpe.2019.406"],"URL":"https:\/\/doi.org\/10.4997\/jrcpe.2019.406","relation":{},"ISSN":["1478-2715","2042-8189"],"issn-type":[{"value":"1478-2715","type":"print"},{"value":"2042-8189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]}}}